1887

Abstract

SUMMARY

Mount Elgon bat virus killed mice up to 13 days of age when given intranasally. Virus reached the brain of these mice via the olfactory nerve route without obvious multiplication in any tissues other than the nasal mucosa of 1- to 6-day-old mice and in the absence of viraemia or circulating virus neutralizing antibody. Large amounts of interferon were, however, synthesized in brain where virus grew to high titres. In mice older than 13 days virus did not multiply in brain but it reached the olfactory bulbs and persisted until virus neutralizing antibody appeared in the nasopharynx. No antibody was detected in blood of the resistant mice, nor was interferon detected in their brains or nasal mucosa. Immunosuppression of the resistant mice with cyclophosphamide resulted in moderate virus growth in mid- and hind-brain accompanied by interferon synthesis and death of the mice. The local immune response prevented invasion of mid- and hind-brain in the resistant mice.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-44-3-587
1979-09-01
2023-02-08
Loading full text...

Full text loading...

/deliver/fulltext/jgv/44/3/JV0440030587.html?itemId=/content/journal/jgv/10.1099/0022-1317-44-3-587&mimeType=html&fmt=ahah

References

  1. Baer G. M. 1976; Post-exposure administration of the interferon system in rabies infected mice and monkeys. In Symposium on Advances in Rabies Research Atlanta: U. S. Department of Health, Education & Welfare;
    [Google Scholar]
  2. Bhatt P. N., Rodrigues F. M. 1967; Chandipura: a new arbovirus isolated in India from patients with febrile illness. Indian Journal of Medical Research 55:1295–1305
    [Google Scholar]
  3. Bradish C. J., Allner K., Fitzgeorge R. 1975; Immunomodification and the expression of virulence in mice by defined strains of Semliki Forest virus: the effects of cyclophosphamide. Journal of General Virology 28:225–237
    [Google Scholar]
  4. Bruno-Lobo M., Perlata P. H., Bruno-Lobo G. G., Paola D. 1968; Pathogenesis of vesicular stomatitis virus infection in the infant hamster and mouse. Annals of Microbiology (Rio de Janeiro) 15:53–68
    [Google Scholar]
  5. Dougherty R. M. 1964 In Techniques in Experimental Virology pp 169–223 Edited by Harris R. C. London, New York: Academic Press;
    [Google Scholar]
  6. Falk D., Rowe W. P. 1965; Die Erkrankung der Maus durch das virus der stomatitis vesicularis. I. Die Ausbrietung des Virus Abhӓngigeit rom Alter der Maus. Archives of Virology 17:549–559
    [Google Scholar]
  7. Fenje P., Posnc B. 1970; Protection of rabbits against experimental rabies by poly 1: poly C. Nature, London 226:171–172
    [Google Scholar]
  8. Gifford G. E. 1963; Studies on the specificity of interferon. Estimation of mouse interferon. Journal of General Microbiology 33:437–443
    [Google Scholar]
  9. Howatson A. F. 1970; Vesicular stomatitis and related viruses. In Advances in Virus Research 16 pp 195–225 Edited by Smith K. M. Lauffer M. A., Bang F. B. London, New York: Academic Press;
    [Google Scholar]
  10. Johnson R. T. 1964; Pathogenesis of herpes virus encephalitis. I. Virus pathway to nervous system of suckling mice demonstrated by fluorescent antibody staining. Journal of Experimental Medicine 119:343–356
    [Google Scholar]
  11. Johnson R. T., Mims C. A. 1968; Pathogenesis of viral infections of the nervous system. New England Journal of Medicine 278:23–30
    [Google Scholar]
  12. Metselaar D., Williams M. C., Simpson D. I. H., West R., Mutere R. A. 1969; Mount Elgon bat virus a hitherto undescribed virus from Rhinolophus hildebrandtii eloquens K. Anderson. Archives of Virology 26:183–193
    [Google Scholar]
  13. Murphy F. A. 1974; Evolution of rhabdovirus tropisms. In Viruses, Evolution and Cancer pp 699–722 Edited by Kurstak E. Maramorosch K. London, New York: Academic Press;
    [Google Scholar]
  14. Murphy F. A. 1977; Rabies pathogenesis. Archives of Virology 54:279–297
    [Google Scholar]
  15. Murphy F. A., Bauer S. P. 1974; Early street rabies virus infection in striated muscle and later progression to the central nervous system. Intervirology 3:256–268
    [Google Scholar]
  16. Murphy F. A., Shope R. E., Meteselaar D., Simpson D. I. H. 1970; Characterization of Mount Elgon bat virus, a new member of the Rhabdovirus group. Virology 40:288–297
    [Google Scholar]
  17. Murphy F. A., Bauer S. P., Harrison A. K., Winn W. C. JUN 1973a; Comparative pathogenesis of rabies and rabies-like viruses: viral infection and transit from inoculation site to the central nervous system. Laboratory Investigation 28:361–376
    [Google Scholar]
  18. Murphy P. A., Harrison A. K., Winn W. C., Bauer S. P. 1973b; Comparative pathogenesis of rabies and rabies-like viruses. Infection of the central nervous system and centrifugal spread of virus to peripheral tissues. Laboratory Investigation 29:1–16
    [Google Scholar]
  19. Nairn R. C. 1976 In Fluorescent Protein Tracing pp 369–372 Edited by Nairn R. C. Edinburgh: Churchill Livingstone;
    [Google Scholar]
  20. Nathanson N., Cole G. A. 1970; Immunosuppression and experimental virus infection of the nervous system. In Advances in Virus Research vol 16 pp 397–438 Edited by Smith K. M., Lauffer M. A., Bang F. B. London, New York: Academic Press;
    [Google Scholar]
  21. Nir Y., Beemer A., Goldwasser R. A. 1965; West Nile virus infection in mice following exposure to virus aerosol. British Journal of Experimental Pathology 46:433–449
    [Google Scholar]
  22. Patel J. R. 1978; A plaque assay for Mount Elgon bat virus based on intrinsic interference. Journal of General Virology 40:659–664
    [Google Scholar]
  23. Rager-Zisman B., Allison A. C. 1973; Effects of immunosuppression of Coxsackie B-3 virus infection in mice and passive protection by circulatory antibody. Journal of General Virology 19:339–351
    [Google Scholar]
  24. Shope R. E., Murphy F. A., Harrison A. K., Causey O. R., Kemp G. E., Simpson D. I. H., Moore D. L. 1970; Two African viruses serologically and morphologically related to rabies virus. Journal of Virology 6:690–692
    [Google Scholar]
  25. Sikes R. W., Cleary W. F., Koprowski H., Wiktor T. J., Kaplan M. M. 1971; Effective protection of monkeys against death from street virus by postexposure administration of tissue culture rabies vaccine. Bulletin of the World Health Organization 45:1–11
    [Google Scholar]
  26. Stewart W. E., Sulkin S. E. 1966; Interferon production in hamsters experimentally infected with rabies virus. Proceedings of the Society for Experimental Biology 123:650–654
    [Google Scholar]
  27. Sulkin S. E., Allen R. 1975; Interferon and rabies virus infection. In The Natural History of Rabies pp 356–373 Edited by Baer G. M. London, New York: Academic Press;
    [Google Scholar]
  28. Tignor G. H., Shope R. E. 1972; Vaccination and challenge of mice with viruses of the rabies serogroup. Journal of Infectious Diseases 125:322–327
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-44-3-587
Loading
/content/journal/jgv/10.1099/0022-1317-44-3-587
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error