1887

Abstract

SUMMARY

A persistent foamy virus infection was established in rabbits and its effect on the cell-mediated (CMI) and humoral immune response was studied. Virus was consistently isolated from viable, peripheral blood mononuclear cells collected 7 to 164 days after inoculation, by co-cultivation, with cell monolayers. The response of leukocytes from infected rabbits to stimulation with phytohaemagglutinin was studied by two techniques: incorporation of H-thymidine and production of the lymphokine, immune interferon. Both parameters of the cell-mediated immune response were depressed in leukocytes collected from foamy virus infected rabbits during the first 2 weeks of the infection. This depression in the cell-mediated immune response was not observed after 14 days p.i. Since primary or reactivation infections with herpes viruses are common following immunosuppression, it was interesting to note that one of the rabbits persistently infected with foamy virus developed a herpes virus infection. The humoral response in infected rabbits appears to be unaffected since the virus infection did not alter the development of antibodies to sheep erythrocytes. Transient depression of the cell-mediated immune response in foamy virus infections may be important in initiating persistence and demonstrates for the first time that foamy viruses can, indeed, have adverse effects.

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1979-08-01
2024-03-29
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References

  1. Armstrong J. A., Evans A. S., Rao N., Ho M. 1976; Viral infections in renal transplant recipients. Infection and Immunity 14:970–975
    [Google Scholar]
  2. Bantfeld H., Vilcek J. 1975; Immunologically specific production of interferon in cultures of rabbit blood lymphocytes: association with in vitro tests for cell-mediated immunity. Infection and Immunity 12:1112–1115
    [Google Scholar]
  3. Burns W. H., Allison A. C. 1975; Virus infections and the immune responses they elicit. In Antigens vol 3 pp 479–574 Edited by Sela M. New York: Academic Press;
    [Google Scholar]
  4. Fenner F. 1976; The classification and nomenclature of viruses. Intervirology 6:1–12
    [Google Scholar]
  5. Fujibayashi T., Hooks J. J., Notkins A. L. 1975; Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes. Journal of Immunology 115:1191–1193
    [Google Scholar]
  6. Hooks J. J. Jun, Gibbs C. J., Cutchins E. C., Rogers N. G., Lampert P., Gajdusek D. C. 1972; Characterization and distribution of two new foamy viruses isolated from chimpanzees. Archiv für die gesamte Virusforschung 38:38–55
    [Google Scholar]
  7. Hooks J. J., Gibbs C. J. Jun 1975; The foamy viruses. Bacteriological Reviews 39:169–185
    [Google Scholar]
  8. Hooks J. J., Burns W. H., Hayashi K., Geis S., Notkins A. L. 1976; Viral spread in the presence of neutralizing antibody: mechanisms of persistence in foamy virus infection. Infection and Immunity 14:1172–1178
    [Google Scholar]
  9. Jacobs R. P., Cole G. A. 1976; Lymphocyte choriomeningitis virus-induced immunosuppression: a virus-induced macrophage defect. Journal of Immunology 117:1004–1009
    [Google Scholar]
  10. Nesburn A. B. 1969; Isolation and characterization of a herpes-like virus from New Zealand albino rabbit kidney cell cultures: a probable re-isolation of virus III of rivers. Journal of Virology 3:59–69
    [Google Scholar]
  11. Notkins A. L. 1975; Appendix-summary of workshop. In Viral Immunology and Immunopathology pp 459–478 Edited by Notkins A. L. New York: Academic Press;
    [Google Scholar]
  12. Oppenheim J. J., Rosenstreich D. L. 1976; Signals regulating in vitro activation of lymphocytes. Progress in Allergy 20:65–194
    [Google Scholar]
  13. Rivers T. M., Tillett W. S. 1923; Studies on Varicella. The susceptibility of rabbits to the virus of Varicella. Journal of Experimental Medicine 38:673–692
    [Google Scholar]
  14. Rytel M., Hooks J. J. 1977; Induction of immune interferon by murine cytomegalovirus. Proceedings of the Society for Experimental Biology and Medicine 155:611–614
    [Google Scholar]
  15. Swack N. S., Hsiung G. D. 1975; Pathogenesis of Simian foamy virus infection in natural and experimental hosts. Infection and Immunity 12:470–474
    [Google Scholar]
  16. Virelizier J. L., Virelizier A., Allison A. C. 1976; The role of circulating interferon in the modification of immune responsiveness by mouse hepatitis virus (MHV-3). Journal of Immunology 117:748–753
    [Google Scholar]
  17. Woodruff J. F., Woodruff J. J. 1975; The effect of viral infections on the function of the immune system. In Viral Immunology and Immunopathology pp 393–418 Edited by Notkins A. L. New York: Academic Press;
    [Google Scholar]
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