1887

Abstract

SUMMARY

Mice of different ages were infected i.p. or i.c. by 23 different strains of VEE virus. The course of the virus host interaction was specified in terms of the efficiency of infection, the outcome of infection as lethality or protection and the survival time. These separately quantifiable features all showed several host-maturation events that combine to provide a multifactorial specification of virus-strains and host-responses. This base-line for correlations with the responses of principal hosts (equidae and man) may be expanded to test correlations with the antigenic or characteristics of virus-strains.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-44-2-373
1979-08-01
2022-01-16
Loading full text...

Full text loading...

/deliver/fulltext/jgv/44/2/JV0440020373.html?itemId=/content/journal/jgv/10.1099/0022-1317-44-2-373&mimeType=html&fmt=ahah

References

  1. Bradish C. J., Fitzgeorge R. 1979; Host-responses to toga-virus infections: the quantitative balances between infection, virulence and immunogenicity for strains of yellow fever virus. In Proceedings of the International Symposium on Chronic Virus Infections, Smolenice, 1977 Slovak Academy of Sciences, Bratislava (in the press)
    [Google Scholar]
  2. Bradish C. J., Allner K., Maber H. B. 1971; The virulence of original and derived strains of Semliki Forest virus for mice, guinea-pigs and rabbits. Journal of General Virology 12:141–160
    [Google Scholar]
  3. Bradish C. J., Allner K., Fitzgeorge R. 1975a; Immunomodification and the expression of virulence in mice and defined strains of Semliki Forest virus: the effect of cyclophosphamide. Journal of General Virology 28:225–237
    [Google Scholar]
  4. Bradish C. J., Allner K., Fitzgeorge R. 1975b; Immunomodification and the expression of virulence in mice by defined strains of Semliki Forest virus: the effect of Myocrisin and 1-asparaginase. Journal of General Virology 28:239–250
    [Google Scholar]
  5. Bradish C. J., Fitzgeorge R., Titmuss D., Baskerville A. 1979; The responses of nude-athymic mice to nominally avirulent togavirus infections. Journal of General Virology 42:555–566
    [Google Scholar]
  6. Halle S., Zebovitz E. 1977; A spontaneous temperature sensitive mutant of Japanese encephalitis virus: preliminary characterization. Archives of Virology 54:165–176
    [Google Scholar]
  7. Hearn H. J. 1960; A variant of Venezuelan equine encephalomyelitis virus attenuated for mice and monkeys. Journal of Immunology 84:626–629
    [Google Scholar]
  8. Helenius A., Morein B., Freis E., Simons K., Robinson P., Schirrmacher V., Terhorst C., Strominger J. 1978; Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus. Proceedings of the National Academy of Sciences of the United States of America 75:3846–3850
    [Google Scholar]
  9. Jahrling P. B., Scherer W. F. 1973; Growth curves and clearance of virulent and benign Venezuelan equine encephalitis viruses in hamsters. Infection and Immunity 8:456–462
    [Google Scholar]
  10. Jahrling P. B., Hilmas D. E., Heard C. D. 1977; Vascular clearance of Venezuelan equine encephalitis viruses as a correlate to virulence for Rhesus monkeys. Archives of Virology 55:161–164
    [Google Scholar]
  11. MacKenzie J. S. 1975; Virulence of temperature-sensitive mutants of foot-and-mouth disease virus. Archives of Virology 48:1–8
    [Google Scholar]
  12. Nathanson N., Cole G. A. 1970; Immunosuppression and experimental virus infection of the nervous system. In Advances in Virus Research 16:397
    [Google Scholar]
  13. Nathanson N., Cole G. A. 1971; Immunosuppression: a means to assess the role of the immune response in acute virus infections. Federation Proceedings 30:1822–1841
    [Google Scholar]
  14. Reed L. J., Muench H. 1938; A simple method of estimating fifty per-cent end points. American Journal of Hygiene 27:493–497
    [Google Scholar]
  15. Walder R., Bradish C. J. 1975; Venezuelan equine encephalitis virus: strain differentiation and the specification of virulence markers. Journal of General Virology 26:265–275
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-44-2-373
Loading
/content/journal/jgv/10.1099/0022-1317-44-2-373
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error