RT Journal Article SR Electronic(1) A1 Stebbing, N.YR 1979 T1 Protection of Mice Against Infection with Wild-type Mengo Virus and an Interferon Sensitive Mutant (IS-1) by Polynucleotides and Interferons JF Journal of General Virology, VO 44 IS 1 SP 255 OP 260 DO https://doi.org/10.1099/0022-1317-44-1-255 PB Microbiology Society, SN 1465-2099, AB SUMMARY Single-stranded polynucleotide preparations [tRNA, poly(rI) plus poly(ho5C)-copolymer] which protect mice against picornavirus infections without inducing interferon, protected mice equally against infection with an interferon-sensitive mutant (IS-1) of Mengo virus and with wild-type virus (IS +). Poly(rI).poly(rC) and mouse macrophage interferon [i.e. serum from mice treated with poly(rI).poly(rC)] protected mice equally against infections with the two viruses, but fibroblast interferon protected better against infection with the interferon-sensitive mutant than with the wild-type virus. These and other results indicate that: Mengo virus has a genetic locus affecting sensitivity to fibroblast but not macrophage interferon; these two types of interferon have different mechanisms of action against Mengo virus infections in mice; Mengo virus genes controlling sensitivity to fibroblast interferon may modulate disease since infection in vivo induces only fibroblast interferon; the antiviral activity of the single-stranded polynucleotides is unlikely to be mediated by induction of either macrophage or fibroblast interferon., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-44-1-255