1887

Abstract

Summary

A previously described revertant cell line (K-BALB SR), derived as a single cell clone from a clonal line of murine fibroblasts (K-BALB) transformed by a nonproductive infection with the Kirsten strain of murine sarcoma virus, has normal morphology and growth kinetics and, unlike the transformed parent cell line, lacks a sarcoma virus that can be rescued. We report here that this reversion correlates with low to undetectable levels of expression of cellular Ki-MSV-specific RNA and a reduction of proviral sequences in the cell DNA to a level equivalent to that found in the uninfected BALB cells with a normal phenotype. The data indicate that phenotypic reversion has occurred as a consequence of the loss of part or all of the sarcoma provirus, either by chromosomal rearrangement or provirus excision.

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/content/journal/jgv/10.1099/0022-1317-44-1-245
1979-07-01
2019-12-08
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-44-1-245
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