1887

Abstract

Summary

Herpes simplex virus type 1 (HSV-1) interfered with the adsorption of subsequently added homotypic but not heterotypic HSV, suggesting that the cellular receptors involved were type-selective. Both infective and u.v.-irradiated virus could block the attachment of virions to cellular surface receptors. The adsorption rate was studied by assaying non-adsorbed infective virus remaining in the fluid medium and cell-associated H-thymidine labelled HSV, and HSV mutants assayed in presence of phosphonoformic acid (PFA). The adsorption profiles indicated that GMK AH-1, Vero and SIRC cells all exhibited more HSV type 1- than type 2-selective receptors while HeLa S3 cells displayed more receptors with affinity for type 2 than for type 1. On HEp-2 and human embryonic lung cells HSV type 1- and type 2-selective receptors were about equally represented.

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/content/journal/jgv/10.1099/0022-1317-44-1-217
1979-07-01
2020-01-24
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-44-1-217
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