RT Journal Article SR Electronic(1) A1 May, G. A1 Fischer, H. A1 Zang, K. D.YR 1979 T1 SV40-Related T-Antigen Expression in Human Meningiomas with Normal and G-22-Monosomic Karyotype JF Journal of General Virology, VO 43 IS 3 SP 697 OP 700 DO https://doi.org/10.1099/0022-1317-43-3-697 PB Microbiology Society, SN 1465-2099, AB SUMMARY Six of 16 meningiomas tested in early subcultures by indirect immunofluorescence showed SV40 T-antigen. Two different antisera specific for T-antigen were used. One serum gave a positive reaction with six tumours and the other with only two. In one T-antigen positive meningioma, the typical nuclear fluorescence changed, beginning with the second subculture, into an unusual brilliant granular pattern irregularly distributed over the nuclei. In six meningiomas, a specific chromosome aberration (monosomy G 22) was established. However, up to now, no clear correlation between karyotype and T-antigen expression could be found: cells from three meningiomas with positive reactions had normal karyotypes, whereas those from three tumours with typical chromosome loss showed no T-antigen., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-43-3-697