1887

Abstract

Summary

Interferon production was inhibited in the Namalwa line of human lymphoblastoid cells by treatment with 2-deoxy--glucose or -glucosamine. -Glucosamine also inhibited protein synthesis and the cells were no longer viable, whereas 2-deoxy--glucose allowed protein and RNA synthesis to continue at control rates, and the cells remained fully viable. It is concluded that a glycosylation step is essential for production of lymphoblastoid interferon.

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/content/journal/jgv/10.1099/0022-1317-43-2-457
1979-05-01
2019-10-14
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-43-2-457
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