%0 Journal Article %A Estes, Mary Kolb %A Graham, David Y. %A Smith, Eric M. %A Gerba, Charles P. %T Rotavirus Stability and Inactivation %D 1979 %J Journal of General Virology, %V 43 %N 2 %P 403-409 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-43-2-403 %I Microbiology Society, %X SUMMARY The stability of the infectivity of Simian rotavirus, SA11, has been analysed and compared to the stability of reovirus type 1. SA11 infectivity was stable to freeze-thawing, sonication, incubation at 25 °C overnight or at 37 °C for 1 h and to treatment with acid, ether, chloroform and Genetron. In contrast to reovirus, the infectivity of SA11 was more rapidly inactivated by heating at 50 °C. SA11 infectivity was inactivated above pH 10.0 and by heating at 50 °C in 2 m-MgCl2, but was stabilized by heating in 2 m-MgSO4; reovirus 1 infectivity was enhanced by heating in MgCl2. Both SA11 and reovirus 1 were inactivated by freezing in MgCl2. These results show that rotaviruses and reoviruses can be distinguished by their patterns of inactivation by physical and chemical agents. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-43-2-403