1887

Abstract

Summary

LLC-MK cells chronically infected with two strains of rubella virus, HPV-77 and Thomas, have been examined over several months to find out the mechanism of persistence. Evidence is given for the presence of defective particles in these cultures by finding virion RNA which sedimented at 12S instead of the 40S typical of the fully infectious virus. A ‘provirus’ DNA copy of the rubella virus genome was not detected by methods which included filter hybridization and hybridization, or by treatment of the chronically infected cells with mitomycin C, actinomycin D or 5-bromodeoxyuridine. In addition, the chronically infected cells contained RNA-dependent RNA polymerase activity, but no RNA-dependent DNA polymerase activity.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-43-2-289
1979-05-01
2019-10-22
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-43-2-289
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error