1887

Abstract

SUMMARY

The effects of mitomycin C and Co γ-irradiation, which induce production of SV40 from SV40-transformed hamster cells, on the replication of superinfecting SV40 or virus DNA in cells varying in permissivity for SV40 replication have been examined. These agents enhance replication of SV40 in an uninducible line of SV40-transformed hamster kidney cells and in nonpermissive secondary hamster kidney cells. The same treatments do not affect SV40 replication in semipermissive hamster (BHK21) and human (HEL, HEK) cells and inhibit SV40 replication in permissive monkey (TC-7) cells. We conclude that forms of induction treatment, such as mitomycin C or Co γ-irradiation, modify the expression of host cell factors which determine the level of permissivity for SV40 infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-43-1-235
1979-04-01
2022-01-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/43/1/JV0430010235.html?itemId=/content/journal/jgv/10.1099/0022-1317-43-1-235&mimeType=html&fmt=ahah

References

  1. Jerkofsky M., Rapp F. 1975; Stimulation of adenovirus replication in simian cells in the absence of a helper virus by pretreatment of the cells with iododeoxyuridine. Journal of Virology 15:253–258
    [Google Scholar]
  2. Kaplan J. C., Wilbert S. M., Collins J. J., Rakusanova T., Zamansky G. B., Black P. H. 1975; Isolation of simian virus 40-transformed inbred hamster cell lines heterogeneous for virus induction by chemicals or radiation. Virology 68:200–214
    [Google Scholar]
  3. Lavialle Ch., Morris A. G., Suarez H. G., Estrade S., Stevenet J., Cassingena R. 1977; Simian virus 40-Chinese hamster kidney cell interaction. IV. Enhanced replication in infected cells upon treatment with mitomycin C. Journal of General Virology 36:137–149
    [Google Scholar]
  4. Rakusanova T., Kaplan J. C., Smales W. P., Black P. H. 1976; Excision of viral DNA from host cell DNA after induction of simian virus 40-transformed hamster cells. Journal of Virology 19:279–285
    [Google Scholar]
  5. Rakusanova T., Smales W. P., Kaplan J. C., Black P. H. 1978; Replication of simian virus 40 in SV40-transformed hamster kidney cells induced by mitomycin C or 60Co γ-irradiation. Virology 88:300–313
    [Google Scholar]
  6. St jeor S., Rapp F. 1973; Cytomegalovirus: conversion of nonpermissive cells to a permissive state for virus replication. Science 181:1060–1061
    [Google Scholar]
  7. Staal S. P., Rowe W. P. 1975; Enhancement of adenovirus infection in WI-38 and AGMK cells by pretreatment of cells with 5-iododeoxyuridine. Virology 64:513–519
    [Google Scholar]
  8. Suarez H. G., Morris A. G., Lavialle Ch., Cassingena R. 1976; Enhanced SV40-virus replication in Chinese hamster kidney cells pretreated with 5-iodo-2′-deoxyuridine. Archives of Virology 50:249–253
    [Google Scholar]
  9. Suarez H. G., Lavialle Ch., Stevenet J., Estrade S., Morris A. G., Cassingena R. 1977; Enhanced SV40 virus replication in fully permissive monkey kidney cells pre-treated with 5-iodo-2′-deoxyuridine (IdUrd). Journal of General Virology 37:569–584
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-43-1-235
Loading
/content/journal/jgv/10.1099/0022-1317-43-1-235
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error