%0 Journal Article %A Ito, Yasuhiko %A Nishiyama, Yukihiro %A Shimokata, Kaoru %A Nagata, Ikuya %A Kunii, Akira %T Interferon Susceptibility of Various Cell Lines Persistently Infected with Haemagglutinating Virus of Japan (HVJ) %D 1979 %J Journal of General Virology, %V 43 %N 1 %P 103-110 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-43-1-103 %I Microbiology Society, %X SUMMARY Various cell lines persistently infected with para-influenza 1 virus, HVJ strain, were less susceptible to the antiviral action of interferon than the same cell lines when not infected with HVJ. When Vero cells persistently infected with a temperature-sensitive strain of HVJ were incubated at 38 °C, a non-permissive temperature, they became fully susceptible to interferon, whereas neither the haemadsorbing nor the cell-associated haemagglutinating activity of the virus was expressed. These findings suggest that the lowered interferon susceptibility of virus-carrier cells may be related to the maturation of virus in them. It was found that the low susceptibility of virus-carrier cells to interferon is not due to blocked adsorption of interferon or to inability of the cells to respond to interferon. Studies with actinomycin D suggest that some step (or steps) before the synthesis of the messenger RNA for the antiviral protein is blocked. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-43-1-103