1887

Abstract

SUMMARY

A persistent infection with rabies virus (HEP-Flury) was established in the CNS-derived hybrid cell line 108 CC15 which possesses specific membrane receptors for prostaglandins, catecholamines and acetylcholine. We report a differential virus influence on the specific receptor response to PGE, isoproterenol and acetycholine as indicated by typical changes of the intracellular cyclic AMP levels.

As the adenylate cyclase activity was unchanged in infected cells , a selective virus influence on specific receptors themselves or their coupling to the cAMP synthesizing system must be considered.

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1979-03-01
2022-01-22
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