%0 Journal Article %A Hofmann, H. %A Frisch-Niggemeyer, W. %A Heinz, F. %T Rapid Diagnosis of Tick-borne Encephalitis by means of Enzyme Linked Immunosorbent Assay %D 1979 %J Journal of General Virology, %V 42 %N 3 %P 505-511 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-42-3-505 %I Microbiology Society, %X SUMMARY An enzyme-linked immunosorbent assay was applied for determining separately IgM and IgG antibodies against tick-borne encephalitis virus. A micro-modification in microtitre plates proved to be at least as sensitive as the HI test. However, more precise information could be achieved by a macrotest using antigen coated polystyrene balls. False positive results in IgM antibody determinations could be caused by a rheumatoid factor. A high content of IgM antibodies in a serum could impair the determination of its IgG antibodies but not vice versa. Titres were expressed in comparison to a positive control serum. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-42-3-505