Skip to content
1887

Abstract

Summary

The infectivity of blood and lymphoid organs of mice persistently infected with lymphocytic choriomeningitis virus was found to be predominantly associated with lymphocytes and both T and B cells were infectious. A hypothesis is presented in which it is assumed that lymphocytes in carrier mice are infected via their LCM virus-specific antigen receptors, thereby leading to their antigen-triggered clonal expansion followed by infection and functional inactivation.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-3-481
1979-03-01
2025-07-14
Loading full text...

Full text loading...

References

  1. Biberfeld P., Biberfeld G., Molnar Z., Fagraeus A. 1974; Fixation of cell-bound antibody in the membrane immunofluorescence test. Journal of Immunological Methods 4:135–148
    [Google Scholar]
  2. Boyum A. 1964; Separation of white blood cells. Nature, London 304:793–794
    [Google Scholar]
  3. Boyum A. 1976; Isolation of lymphocytes, granulocytes and macrophages. Scandinavian Journal of Immunology 5: (Suppl. 5) 9–15
    [Google Scholar]
  4. Brown P. 1968; Evolution of lymphocytic choriomeningitis virus infection from neonatal inoculation through development of adult ‘late onset disease’ and glomerulonephritis. An immunofluorescence study in mice. Archiv fur die gesamte Virusforschung 24:220–230
    [Google Scholar]
  5. Cihak J., Lehmann-Grube F. 1974; Persistent infection of mice with the virus of lymphocytic choriomeningitis: virus-specific immunological tolerance. Infection and Immunity 10:1072–1076
    [Google Scholar]
  6. Cihak J., Lehmann-Grube F. 1978; Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism. Immunology 34:265–275
    [Google Scholar]
  7. Eustatia J. M., Van Der Veen J. 1971; Viral replication in cultures of phytohemagglutinin-treated mouse lymphocytes. Proceedings of the Society for Experimental Biology and Medicine 137:424–428
    [Google Scholar]
  8. Falk R. E., Collste L., Moller G. 1970; In vitro detection of transplantation immunity: the inhibition of migration of immune spleen cells and peripheral blood leukocytes by specific antigen. Journal of Immunology 104:1287–1292
    [Google Scholar]
  9. Good N. E., Winget D. G., Winter W., Connolly T. N., Izawa S., Singh R. M. M. 1966; Hydrogen ion buffers for biological research. Biochemistry 5:467–477
    [Google Scholar]
  10. Gschwender H. H., Rutter G., Lehmann-Grube F. 1976; Lymphocytic choriomeningitis virus. II. Characterization of extractable complement-fixing activity. Medical Microbiology and Immunology 162:119–131
    [Google Scholar]
  11. Julius M. H., Simpson E., Herzenberg L. A. 1973; A rapid method for the isolation of functional thymus-derived murine lymphocytes. European Journal of Immunology 3:645–649
    [Google Scholar]
  12. Kano S., Bloom B. R., Howe M. L. 1973; Enumeration of activated thymus-derived lymphocytes by the virus plaque assay. Proceedings of the National Academy of Sciences of the United States of America 70:2299–2303
    [Google Scholar]
  13. Leder L.-D. 1967 In Der Blutmonocyt Berlin, Heidelberg, New York: Springer-Verlag;
    [Google Scholar]
  14. Lehmann-Grube F. 1964; Lymphocytic choriomeningitis in the mouse. II. Establishment of carrier colonies. Archiv fiir die gesamte Virusforschung 14:351–357
    [Google Scholar]
  15. Lehmann-Grube F. 1971; Lymphocytic Choriomeningitis Virus. In Virology Monographs vol 10 Wien and New York: Springer-Verlag;
    [Google Scholar]
  16. Lockart R. Z., Eagle H. 1959; Requirements for growth of single human cells. Science 129:252–254
    [Google Scholar]
  17. Löhler J., Ehlerding I., Lehmann-Grube F. 1974; Pathologie des lymphatischen Gewebes bei der Lymphozytaren Choriomeningitis der Maus. Zentralblatt für Bakteriologie, Parasitenkunde, Infek, tionskrankheiten und Hygiene, Abteilung I Originate A 227:458–468
    [Google Scholar]
  18. Mims C. A. 1966; Immunofluorescence study of the carrier state and mechanism of vertical transmission in lymphocytic choriomeningitis virus infection in mice. Journal of Pathology and Bacteriology 91:395–402
    [Google Scholar]
  19. Mims C. A., Wainwright S. 1968; The immunodepressive action of lymphocytic choriomeningitis virus in mice. Journal of Immunology 101:717–724
    [Google Scholar]
  20. Murphy F. A., Whitfield S. G. 1975; Morphology and morphogenesis of arenaviruses. Bulletin of the World Health Organization 52:409–419
    [Google Scholar]
  21. Olding L. B., Kingsbury D. T., Oldstone M. B. A. 1976; Pathogenesis of cytomegalovirus infection. Distribution of viral products, immune complexes and autoimmunity during latent murine infection. Journal of General Virology 33:267–280
    [Google Scholar]
  22. Popescu M., Lehmann-Grube F. 1976; Diversity of lymphocytic choriomeningitis virus: variation due to replication of the virus in the mouse. Journal of General Virology 30:113–122
    [Google Scholar]
  23. Popescu M., Lohler J., Lehmann-Grube F. 1977; Infectious lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus. Zeitschrift für Naturforschung 32c:1026–1028
    [Google Scholar]
  24. Popescu M., Schaefer H., Lehmann-Grube F. 1976; Homologous interference of lymphocytic choriomeningitis virus: detection and measurement of interference focus-forming units. Journal of Virology 20:1–8
    [Google Scholar]
  25. Rivers T. M., Scott T. F. M. 1936; Meningitis in man caused by a filterable virus. II. Identification of the etiological agent. Journal of Experimental Medicine 63:415–432
    [Google Scholar]
  26. Schwartz R., Lohler J., Lehmann-Grube F. 1978; Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus. Journal of General Virology 39:565–570
    [Google Scholar]
  27. Schwenk H.-U., Lehmann-Grube F. 1971; Phytohamagglutinin-induzierter Thymidineinbau in Lympho-zyten persistierend LCM-virusinfizierter Mause. In Leukozytenkulturen pp 147–150 Edited by Brittinger G., Rcggenbach H. J. Stuttgart and New York: F. K. Schattauer Verlag;
    [Google Scholar]
  28. Traub E. 1936; Persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity. Journal of Experimental Medicine 63:847–861
    [Google Scholar]
  29. Traub E. 1938; Factors influencing the persistence of choriomeningitis virus in the blood of mice after clinical recovery. Journal of Experimental Medicine 68:329–250
    [Google Scholar]
  30. Trizio D., Cudkowicz G. 1974; Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo. Journal of Immunology 113:1093–1097
    [Google Scholar]
  31. Volkert M., Bro-Jgrgensen K., Marker O. 1975; Persistent LCM virus infection in the mouse. Immunity and tolerance. Bulletin of the World Health Organization 52:471–478
    [Google Scholar]
  32. Weller T. H., Coons A. H. 1954; Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro. Proceedings of the Society for Experimental Biology and Medicine 86:789–794
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-42-3-481
Loading
/content/journal/jgv/10.1099/0022-1317-42-3-481
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error