1887

Abstract

SUMMARY

In G1-arrested cells infected between 1 and 12 h after having been stimulated by fresh serum to progress to S phase, polyoma virus DNA synthesis proceeded in the first half of S phase, and virus and whole cellular DNA accumulated at about the same time. However, in cells infected later than 14 h after serum stimulation, virus DNA synthesis was shifted to the next S phase. Thus, a permissive cell attains competence for polyoma virus DNA replication at a precise moment during an S phase initiated by fresh serum, which can efficiently replace the early virus host DNA stimulation function. When cells were incubated in serum that had lost its capacity to stimulate host DNA synthesis by pre-absorption with growing cells, normal yields of polyoma DNA could nevertheless be observed, which shows that extensive replication of host DNA does not seem to be an obligatory condition for virus DNA replication.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-2-429
1979-02-01
2021-10-16
Loading full text...

Full text loading...

/deliver/fulltext/jgv/42/2/JV0420020429.html?itemId=/content/journal/jgv/10.1099/0022-1317-42-2-429&mimeType=html&fmt=ahah

References

  1. Balazs I., Brown E. H., Schildkraut C. L. 1973; The temporal order of replication of some DNA cistrons. Cold Spring Harbor Symposium on Quantitative Biology 38:239–245
    [Google Scholar]
  2. Cassio D., Robert-Gero M., Shire D. J., Waller J. P. 1973; Effect of methioninyl adenylate on the growth of E. coli K12. FEBS Letters 35:112–116
    [Google Scholar]
  3. Cramer R., Feinendegen L. E. 1966; Incorporation de thymidine dans l’ADN de cellules de souris et de hamsters infectés par le virus polyome. International Journal of Cancer 1:149–160
    [Google Scholar]
  4. Crawford L. V. 1969; Nucleic acids of tumor viruses. Advances in Virus Research 14:89–101
    [Google Scholar]
  5. Eckhart W. 1974; Properties of temperature-sensitive mutants of polyoma virus. Cold Spring Harbor Symposium on Quantitative Biology 39:37–44
    [Google Scholar]
  6. Hatfield I. M. R., Walker P. M. B. 1973; Satellite DNA replication in baby mouse kidney cells infected with polyoma virus. Nature New Biology 242:141–142
    [Google Scholar]
  7. Hirt B. 1967; Selective extraction of polyoma DNA from infected mouse cell cultures. Journal of Molecular Biology 26:365–369
    [Google Scholar]
  8. Manteuil S., Pages S., Stehelin D., Girard M. 1973; Replication of SV40 deoxyribonucleic acid: analysis of the one step growth cycle. Journal of Virology 11:98–106
    [Google Scholar]
  9. Nordenskjold B. A., Skoog L., Brown N. C., Reichard P. 1970; Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in cultured mouse embryo cells. Journal of Biological Chemistry 245:5360–5368
    [Google Scholar]
  10. Pages J., Manteuil S., Stehelin D., Fiszman M., Marx M., Girard M. 1975; Relationship between replication of Simian virus 40 DNA and specific event of the host cell cycle. Journal of Virology 17:99–107
    [Google Scholar]
  11. Pardee A. B. 1974; A restriction point for control of normal animal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 71:1286–1290
    [Google Scholar]
  12. Prescott D. M. 1976 In Reproduction of Eukaryotic Cells New York: Academic Press;
    [Google Scholar]
  13. Radloff R., Bauer W., Vinograd J. 1967; A dye-buoyant-density method of the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America 57:1514–1521
    [Google Scholar]
  14. Rhode S. L. 1973; Replication process of the Parvovirus H-I. I. Kinetics in a parasynchronous cell system. Journal of Virology 11:856–861
    [Google Scholar]
  15. Ritzi A., Levine A. J. 1970; Deoxyribonucleic acid replication in SV40-infected cells. Comparison of SV40 lytic infection in three different monkey kidney cell lines. Journal of Virology 5:686–692
    [Google Scholar]
  16. Robert-Gero M., Lawrence F., Farrugia G., Berneman A., Blanchard P., Vigier P., Lederer E. 1975; Inhibition of virus-induced cell transformation by synthetic analogues of S-adenosyl homocysteine. Biochemical and Biophysical Research Communications 65:1242–1249
    [Google Scholar]
  17. Salomon C., Turler H., Weil R. 1977; Polyoma-induced stimulation of cellular RNA synthesis is paralleled by changed expression of the viral genome. Nucleic Acids Research 4:1483–1502
    [Google Scholar]
  18. Smith B. J. 1970 In The Biology of Oncogenic Viruses (Lepetit Symposium)
    [Google Scholar]
  19. Thorne H. V. 1973a; Cyclic variation in susceptibility of Balb-c 3T3 cells to polyoma virus. Journal of General Virology 18:163–169
    [Google Scholar]
  20. Thorne H. V. 1973b; An investigation of factors influencing the susceptibility of Balb-c 3T3 cells to polyoma virus. Journal of General Virology 18:153–162
    [Google Scholar]
  21. Todaro G. J., Green H. 1965; The initiation of cell division in a contact-inhibited mammalian cell line. Journal of Comparative Cellular Physiology 66:325–334
    [Google Scholar]
  22. Yoshikura H., Hirokawa Y., Yamada M. 1967; Synchronized cell division induced by medium change. Experimental Cell Research 48:226–228
    [Google Scholar]
  23. Yoshikura H., Hirokawa Y. 1968; Induction of cell replication. Experimental Cell Research 52:439–444
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-2-429
Loading
/content/journal/jgv/10.1099/0022-1317-42-2-429
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error