1887

Abstract

Summary

Of ninety-one subcultured foci of SV40-transformed WI-38 human diploid fibroblasts, none yielded cells that grew indefinitely, but all cells in each subculture continued to produce T antigen and to look morphologically transformed throughout their lifespan. These results are consistent with the commitment theory of fibroblast senescence, but predict that a special transformation event is necessary to account for the rare survivors.

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/content/journal/jgv/10.1099/0022-1317-42-2-409
1979-02-01
2019-10-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-2-409
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