1887

Abstract

Summary

The intracerebral (i.c.) injection of mice with a particular source of hamster passaged scrapie produced disease after an incubation period of 325 ± 6 days (mean ± s.e.). The incubation period at the second i.c. passage in mice was reduced to 149 ± 2 days. Studies were made of the dynamics of agent replication at 1st and 2nd passages in mice. At first passage, there was a ‘zero phase’ lasting about 175 days, when no infectious agent was detected in brain (or spleen), followed by a period of agent replication which lasted 150 days. At second passage, there was no significant ‘zero phase’ and agent replication occupied the whole of the incubation period. The occurrence of a ‘zero phase’ on interspecies passage of scrapie is discussed in relation to other reports of a ‘zero phase’ in mouse passaged scrapie.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-1-107
1979-01-01
2019-10-22
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-1-107
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error