1887

Abstract

SUMMARY

The intracerebral (i.c.) injection of mice with a particular source of hamster passaged scrapie produced disease after an incubation period of 325 ± 6 days (mean ± s.e.). The incubation period at the second i.c. passage in mice was reduced to 149 ± 2 days. Studies were made of the dynamics of agent replication at 1st and 2nd passages in mice. At first passage, there was a ‘zero phase’ lasting about 175 days, when no infectious agent was detected in brain (or spleen), followed by a period of agent replication which lasted 150 days. At second passage, there was no significant ‘zero phase’ and agent replication occupied the whole of the incubation period. The occurrence of a ‘zero phase’ on interspecies passage of scrapie is discussed in relation to other reports of a ‘zero phase’ in mouse passaged scrapie.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-1-107
1979-01-01
2024-04-23
Loading full text...

Full text loading...

/deliver/fulltext/jgv/42/1/JV0420010107.html?itemId=/content/journal/jgv/10.1099/0022-1317-42-1-107&mimeType=html&fmt=ahah

References

  1. Dickinson A. G. 1978 In Slow Virus Diseases of Animals and Man, Frontiers of Biology series vol 441 chapter 10 pp 209–241 Edited by Kimberlin R. H. Amsterdam and New York: North Holland;
    [Google Scholar]
  2. Dickinson A. G., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in mouse spleen. Journal of Comparative Pathology 79:363–366
    [Google Scholar]
  3. Dickinson A. G., Meikle V. M. H., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in the brain of mice. Journal of Comparative Pathology 79:15–22
    [Google Scholar]
  4. Dickinson A. G., Fraser H., Outram G. W. 1975; Scrapie incubation time can exceed natural lifespan. Nature, London 256:732–733
    [Google Scholar]
  5. Dickinson A. G., Fraser H. 1977 In Slow Virus Infections of the Central Nervous System chapter 1 pp 3–14 Edited by ter Meulen V., Katz M. New York: Springer-Verlag;
    [Google Scholar]
  6. Dickinson A. G., Fraser H., McConnell I., Outram G. W. 1978; Mitogenic stimulation of the host enhances susceptibility to scrapie. Nature, London 272:54–55
    [Google Scholar]
  7. Hotchin J., Buckley R. 1977; Latent form of scrapie virus: a new factor in slow-virus disease. Science 196:668–671
    [Google Scholar]
  8. Kimberlin R. H. 1976 In Scrapie in the Mouse Patterns of Progress, Microbiology series, vol 5 77 pages. Shildon, Co Durham, England: Meadowfield Press Ltd;
    [Google Scholar]
  9. Kimberlin R. H., Cunnington P. G. 1978; Reduction of scrapie incubation time in mice and hamsters by a single injection of methanol extraction residue of BCG. FEMS Letters 3:169–172
    [Google Scholar]
  10. Kimberlin R. H., Millson G. C. 1976; The effects of cuprizone toxicity on the incubation period of scrapie in mice. Journal of Comparative Pathology 86:489–496
    [Google Scholar]
  11. Kimberlin R. H., Walker C. A. 1977; Characteristics of a short incubation model of scrapie in the golden hamster. Journal of General Virology 34:295–304
    [Google Scholar]
  12. Kimberlin R. H., Walker C. A. 1978a; Evidence that the transmission of one source of scrapie agent to hamsters involves separation of agent strains from a mixture. Journal of General Virology 39:487–496
    [Google Scholar]
  13. Kimberlin R. H., Walker C. A. 1978b; Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves. Journal of Comparative Pathology 88:39–47
    [Google Scholar]
  14. Kimberlin R. H., Walker C. A., Millson G. C. 1975; Interspecies transmission of scrapie-like diseases. Lancet ii:1309–1310
    [Google Scholar]
  15. Marsh R. F. 1976 In Slow Virus Diseases of Animals and Man Frontiers of Biology series, vol 44 chapter 15 pp 359–380 Edited by Kimberlin R. H. Amsterdam and New York: North Holland;
    [Google Scholar]
  16. Outram G. W. 1976 In Slow Virus Diseases of Animals and Man Frontiers of Biology series, vol 44 chapter 14 pp 325–357 Edited by Kimberlin R. H. Amsterdam and New York: North Holland;
    [Google Scholar]
  17. Outram G. W., Dickinson A. G., Fraser H. 1974; Reduced susceptibility to scrapie in mice after steroid administration. Nature, London 249:855–856
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-1-107
Loading
/content/journal/jgv/10.1099/0022-1317-42-1-107
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error