@article{mbs:/content/journal/jgv/10.1099/0022-1317-41-2-437, author = "Cowan, K. M. and Erol, N. and Whiteland, A. P.", title = "Effect of Trypsin Treatment on the Antigenic Characteristics of Plaque Variants of Type O1 and Type Asia-1 Foot-and-Mouth Disease Viruses", journal= "Journal of General Virology", year = "1978", volume = "41", number = "2", pages = "437-442", doi = "https://doi.org/10.1099/0022-1317-41-2-437", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-41-2-437", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Summary Antigenic differences were demonstrated between the large and small plaque variants of both types O1 and Asia-1 foot-and-mouth disease viruses. Treatment of the large and small plaque variants of the viruses with trypsin essentially abolished the observed antigenic differences. Thus, these plaque variants have antigenically different trypsin-sensitive determinants that may influence their immunogenicity and infection capabilities.", }