1887

Abstract

SUMMARY

The proteins induced by infection of BHK 21 cells with foot-and-mouth disease virus have been compared by tryptic peptide analysis. The results indicate that there are three primary products 5′–P88, P52, P100–3′. The polypeptide P56, which we considered previously to be a primary product, is derived from the region of the genome that codes for P100. The results indicate that there are alternative cleavage pathways of P100, the polypeptide coded for by the 3′ end of the genome.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-41-2-395
1978-11-01
2024-12-13
Loading full text...

Full text loading...

/deliver/fulltext/jgv/41/2/JV0410020395.html?itemId=/content/journal/jgv/10.1099/0022-1317-41-2-395&mimeType=html&fmt=ahah

References

  1. Burroughs N., Doel T., Brown F. 1978; Relationship of San Miguel sea lion virus to other members of the calicivirus group. Intervirology in the press
    [Google Scholar]
  2. Cleveland D. W., Fischer S. C., Kirschner M. W., Laemmli U. K. 1977; Peptide mapping by limited proteolysis in sodium dodecyl sulphate and analysis by gel electrophoresis. Journal of Biological Chemistry 252:1102–1106
    [Google Scholar]
  3. Doel T. R., Brown F. 1978; Tryptic peptide analysis of the structural proteins of vesicular stomatitis virus. Journal of General Virology 38:351–361
    [Google Scholar]
  4. Fairbanks G., Levinthal C., Reeder R. H. 1965; Analysis of 14C-labelled proteins by disc electrophoresis. Biochemical and Biophysical Research Communications 20:393–399
    [Google Scholar]
  5. Harris T. J. R., Doel T. R., Brown F. 1977; Molecular aspects of the antigenic variation of swine vesicular disease and Coxsackie B5 viruses. Journal of General Virology 35:299–315
    [Google Scholar]
  6. Kiehn E. D., Holland J. J. 1970; Synthesis and cleavage of enterovirus polypeptides in mammalian cells. Journal of Virology 5:358–367
    [Google Scholar]
  7. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, London 227:680–685
    [Google Scholar]
  8. Mclean C., Matthews T. J., Rueckert R. R. 1976; Evidence of ambiguous processing and selective degradation in the noncapsid proteins of rhinovirus I A. Journal of Virology 19:903–914
    [Google Scholar]
  9. Rekosh D. 1977; The molecular biology of picornaviruses. In The Molecular Biology of Animal Viruses 163–110 Nayak D. P. New York: Marcel Dekker;
    [Google Scholar]
  10. Sangar D. V., Blackjd N., Rowlands D. J., Brown F. 1977; Biochemical mapping of the foot-and-mouth disease virus genome. Journal of General Virology 35:281–297
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-41-2-395
Loading
/content/journal/jgv/10.1099/0022-1317-41-2-395
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error