1887

Abstract

SUMMARY

Reversion to virulence of dog kidney cell attenuated canine distemper virus (CDV), Rockborn strain, was demonstrated after serial passage in dogs. The same strain also reverted to virulence after serial passage in canine macrophage cultures. Criteria for virulence in dogs included clinical signs, weight loss, elevated body temperatures, reduced total lymphocyte counts, impaired blastogenesis responses of blood lymphocytes, appearance of virus antigen in epithelial cells, the character of neutralizing antibody responses and the capability of re-isolated virus to grow in canine macrophage cultures.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-41-2-385
1978-11-01
2024-12-07
Loading full text...

Full text loading...

/deliver/fulltext/jgv/41/2/JV0410020385.html?itemId=/content/journal/jgv/10.1099/0022-1317-41-2-385&mimeType=html&fmt=ahah

References

  1. Appel M. J. G. 1969; Pathogenesis of canine distemper. American Journal of Veterinary Research 30:1167–1182
    [Google Scholar]
  2. Appel M. J. G., Gillespie J. H. 1972; Canine distemper virus. Virology Monographs II:3–96
    [Google Scholar]
  3. Appel M. J. G., Jones O. R. 1967; Use of alveolar macrophages for cultivation of canine distemper virus. Proceedings of the Society for Experimental Biology and Medicine 126:571–574
    [Google Scholar]
  4. Appel M., Robson D. S. 1973; A microneutralization test for canine distemper virus. American Journal of Veterinary Research 34:1459–1463
    [Google Scholar]
  5. Bang F. B., Warwick A. 1960; Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. Proceedings of the National Academy of Sciences of the United States of America 46:1065–1075
    [Google Scholar]
  6. Brooke J. H. 1962; A simple method of preparing phytohemagglutinin. Mammalian Chromosomes Newsletter 7:15–16
    [Google Scholar]
  7. Clark H. F. 1978; Rabies viruses increase in virulence when propagated in neuroblastoma cell cultures. Science 199:1072–1075
    [Google Scholar]
  8. Goto H., Shen D. T., Gorham J. R. 1976; Reversion to virulence of an attenuated distemper virus vaccine strain induced by rapid serial passage in ferrets. Federation Proceedings 35:1021 abstract
    [Google Scholar]
  9. Harrison M. J., Oxer D. T., Smith F. A. 1968; The virus of canine distemper in cell culture. II. Effect of serial passage in ferret kidney cell cultures and BS-C-1 cultures on the virulence of canine distemper virus. Journal of Comparative Pathology 78:133–139
    [Google Scholar]
  10. Homma M., Ohuchi M. 1973; Trypsin action on the growth of Sendai virus in tissue culture cells. III. Structural difference of Sendai viruses grown in eggs and tissue culture cells. Journal of Virology 12:1457–1465
    [Google Scholar]
  11. Imagawa D. T., Goret P., Adams J. M. 1960; Immunological relationship of measles, distemper, and rinderpest viruses. Proceedings of the National Academy of Sciences of the United States of America 47:1119–1123
    [Google Scholar]
  12. Kantoch M. 1978; Markers and vaccines. Advances in Virus Research 22:259–325
    [Google Scholar]
  13. Mims C. A. 1964; Aspects of the pathogenesis of virus diseases. Bacteriological Reviews 28:30–71
    [Google Scholar]
  14. Nagai Y., Klenk H.-D., Rott R. 1976; Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus. Virology 72:494–508
    [Google Scholar]
  15. Olson L. C., Sithisarn P., Duinawi N. K. 1975; Role of macrophages in Wesselsbron and Germiston virus infections of mice. Journal of Infectious Diseases 131:119–128
    [Google Scholar]
  16. Poste G. 1971; The growth and cytopathogenicity of virulent and attenuated strains of canine distemper virus in dog and ferret macrophages. Journal of Comparative Pathology 81:49–54
    [Google Scholar]
  17. Rockborn G. 1958; Canine distemper virus in tissue culture. Archiv fur die Gesamte Virusforschung 8:485–492
    [Google Scholar]
  18. Rockborn G. 1959; An attenuated strain of canine distemper virus in tissue culture. Nature, London 184:822
    [Google Scholar]
  19. Schultz R. D. 1977; Laboratory diagnosis of immunologic disorders. In Current Veterinary Therapy, 6.453–463 Kirk R. W. Philadelphia: W. B. Saunders Company;
    [Google Scholar]
  20. Stevens J. O., Cook M. L. 1971; Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. Journal of Experimental Medicine 133:19–38
    [Google Scholar]
  21. Sullivan J. L., Barry D. W., Lucas S. J., Albrecht P. 1975; Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes. Journal of Experimental Medicine 142:773–784
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-41-2-385
Loading
/content/journal/jgv/10.1099/0022-1317-41-2-385
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error