1887

Abstract

SUMMARY

Mice could be significantly protected against infection with herpes simplex virus (HSV) by i.p. or i.v. injection of killed 7 days before infection. This protection was seen in inbred strains of mice with a different degree of sensitivity to HSV and after both i.p. and i.v. infection. Resistant mice immuno-suppressed by X-irradiation and showing an increased susceptibility to HSV could also be protected by a previous injection of . Elevated levels of interferon were demonstrated in the serum of mice injected with 5 to 12 days previously. Four different strains of anaerobic coryneforms were compared and only those which were able to induce a systemic activation of the lymphoreticular system (as reflected by splenomegaly) protected against HSV infection. Protection against HSV-infection could also be demonstrated by using killed also protected against Semliki Forest virus infection in two different strains of mice.

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1978-10-01
2021-10-26
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References

  1. Adlam C., Scott M. T. 1973; Lymphoreticular stimulatory properties of Corynebacterium parvum and related bacteria. Journal of Medical Microbiology 6:261–274
    [Google Scholar]
  2. Allison A. C. 1974; On the role of mononuclear phagocytes in immunity against viruses. Progress in Medical Virology 18:15–31
    [Google Scholar]
  3. Bang F. B., Warwick A. 1960; Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis for their susceptibility. Proceedings of the National Academy of Sciences of the United States of America 46:1065–1075
    [Google Scholar]
  4. Baum M., Breese M. 1976; Antitumour effect of Corynebacterium parvum Possible mode of action. British Journal of Cancer 33:468–473
    [Google Scholar]
  5. Borecky L., Lackovic V. 1967; The cellular background of interferon production in vivo. Comparison of interferon induction by Newcastle Disease virus and Bordetella pertussis . Acta Virologica 11:150–158
    [Google Scholar]
  6. Bradish C. J., Allner K. 1972; The early responses of mice to respiratory or intraperitoneal infection by defined virulent and avirulent strains of Semliki Forest virus. Journal of General Virology 15:205–218
    [Google Scholar]
  7. Farber P. A., Glasgow A. L. 1972; Effect of Corynebacterium acnes on interferon production in mice. Infection and Immunity 6:272–276
    [Google Scholar]
  8. Floersheim G. L. 1967; Facilitation of tumour growth by Bacillus pertussis . Nature, London 216:1235–1236
    [Google Scholar]
  9. Glasgow L. A., Fischbach J., Bryant S. M., Kern E. R. 1977; Immunomodulation of host resistance to experimental viral infections in mice. Effects of Corynebacterium acnes, Corynebacterium parvum, and Bacille Calmette-Guerin. Journal of Infectious Diseases 135:763–770
    [Google Scholar]
  10. Hirt H. M., Becker H., Kirchner H. 1978; Induction of interferon production in mouse spleen cell cultures by Corynebacterium parvum . Cellular Immunology (in the press)
    [Google Scholar]
  11. Ho M., Armstrong J. A. 1975; Interferon. Annual Reviews of Microbiology 29:131–161
    [Google Scholar]
  12. Kirchner H., Glaser M., Herberman R. B. 1975; Suppression of cell-mediated tumour immunityby Corynebacterium parvum . Nature, London 257:396–398
    [Google Scholar]
  13. Kirchner H., Hirt H. M., Kleinicke C., Munk K. 1976; Replication of herpes simplex virus in mouse spleen cell cultures stimulated by lipopolysaccharide. Journal of Immunology 117:1753–1756
    [Google Scholar]
  14. Kirchner H., Hirt H. M., Munk K. 1977a; Protection against herpes simplex virus infection in mice by Corynebacterium parvum . Infection and Immunity 16:9–11
    [Google Scholar]
  15. Kirchner H., Hirt H. M., Becker H., Munk K. 1977b; Production of an antiviral factor by murine spleen cells after treatment with Corynebacterium parvum . Cellular Immunology 31:172–176
    [Google Scholar]
  16. Kirchner H., Kochen M., Hirt H. M., Munk K. 1978; Immunological studies of HSV-infection of resistant and susceptible strains of mice. Zeitschrift für Immunitätsforschung und experimentelle Therapie 153:147–154
    [Google Scholar]
  17. Likhite V. V. 1974; Rejection of mammary adenocarcinoma cell tumors and the prevention of progressive growth of incipient metastases following intratumour permeation with killed Bordetella pertussis . Cancer Research 34:2790–2794
    [Google Scholar]
  18. Lopez C. 1975; Genetics of natural resistance to herpesvirus infections in mice. Nature, London 258:152–153
    [Google Scholar]
  19. Morahan P. S., Kern E. A., Glasgow L. A. 1977; Immunomodulator-induced resistance against herpes simplex virus. Proceedings of the Society for Experimental Biology and Medicine 154:615–620
    [Google Scholar]
  20. Morse S. I., Riester S. K. 1967; Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis. Journal of Experimental Medicine 125:401–408
    [Google Scholar]
  21. Purnell D. M., Kreider J. W., Bartlett O. L. 1975; Evaluation of antitumor activity of Bordetella pertussis in two murine tumor models. Journal of the National Cancer Institute 55:123–128
    [Google Scholar]
  22. Scott M. T. 1972; Biological effects of the adjuvant Corynebacterium parvum I. Inhibition of PHA, mixed lymphocyte and GvH reactivity. Cellular Immunology 5:459–468
    [Google Scholar]
  23. Scott M. T. 1974; Corynebacterium parvum as an immunotherapeutic anticancer agent. Seminars in Oncology 1:367–378
    [Google Scholar]
  24. Starr S. E., Visintine A. M., Tomeh M. O., Nahmias A. J. 1976; Effects of immunostimulants on resistance of newborn mice to herpes simplex type 2 infection. Proceedings of the Society for Experimental Biology amd Medicine 152:57–60
    [Google Scholar]
  25. Stevens J. G., Cook M. L. 1971; Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. Journal of Experimental Medicine 133:19–38
    [Google Scholar]
  26. Woodruff M. F. A., Ghaffar A., Whitehead V. L. 1976; Modification of the effect of C. parvum on macrophage activity and tumor growth by X-irradiation. International Journal of Cancer 17:652–658
    [Google Scholar]
  27. Zisman B., Hirsch M. S., Allison A. C. 1970; Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum in pathogenesis of herpes virus infection of young adult mice. Journal of Immunology 104:1155–1159
    [Google Scholar]
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