Mink lung cells (MvILu) are highly susceptible to varicella-zoster virus (VZV). The titres of cell-free VZV suspensions reached 1·0 × 10 p.f.u./ml at 3 days postinfection, with subsequent cell degeneration, if MvILu cells were infected with a multiplicity of infectious virus of 0·01 p.f.u./cell. In contrast, during the same period and under the same conditions the titres of cell-free VZV were 10 to 10 times lower when grown on human foreskin fibroblasts. A fast and reliable plaque assay and a neutralization test for VZV on MvILu cells, were developed.


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  1. Caunt A. E. 1963; Growth of varicella-zoster virus in human thyroid tissue cultures. Lancet ii:982–983
    [Google Scholar]
  2. Darai G., Munk K. 1976; Neoplastic transformation of rat embryo cells with herpes simplex virus.. International Journal of Cancer 18:469–481
    [Google Scholar]
  3. Schmidt N., Lennette E. A. 1976; Improved yields of cell-free varicella-zoster virus.. Journal of Virology 14:709–715
    [Google Scholar]
  4. Taylor-robinson D., Caunt A. E. 1972; Varicella virus. In Virology Monographs 12:20–21 Gard S., Hallauer C., Meyer K. F. New York: Springer Verlag;
    [Google Scholar]
  5. Weller T. H., Witton H. M., Bell E. J. 1958; The etiologic agents of varicella and herpes zoster. Isolation, propagation and cultural characteristics in vitro. Journal of Experimental Medicine 108:843–868
    [Google Scholar]

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