1887

Abstract

SUMMARY

Calcium chloride (5 to 20 m) potentiated interferon production induced by rI:rC in L929 mouse fibroblasts up to a thousand-fold. Higher concentrations of calcium (20 to 65 m) mixed with rI:rC were associated with increased cytotoxicity and a more acidic medium, but were effective in enhancing interferon production if preparations were adjusted to a uniform pH. Although calcium increased cellular binding of H-rC:rI, only a partial correlation between binding and interferon production was observed.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-40-2-485
1978-08-01
2022-08-13
Loading full text...

Full text loading...

/deliver/fulltext/jgv/40/2/JV0400020485.html?itemId=/content/journal/jgv/10.1099/0022-1317-40-2-485&mimeType=html&fmt=ahah

References

  1. Bausek G. H., Merigan T. C. 1969; Cell interaction with a synthetic polynucleotide and interferon production in vitro . Virology 39:491–498
    [Google Scholar]
  2. Billiau A., Buckler C. E., Dianzani F., Uhlendorf C., Baron S. 1970; Influence of basic substances on the induction of the interferon mechanism. Annals of the New York Academy of Sciences 173:657–667
    [Google Scholar]
  3. Borden E. C., Leonhardt P. H. 1976; Enhancement of rIn:rCn-induced interferon production by amphotericin B. Antimicrobial Agents and Chemotherapy 9:551–553
    [Google Scholar]
  4. Borden E. C., Booth B. W., Leonhardt P. H. 1977; Mechanistic studies of polyene enhancement of interferon production by poly rIn:rCn . Antimicrobial Agents and Chemotherapy (in the press)
    [Google Scholar]
  5. Borden E. C., Leonhardt P. H. 1977; A quantitative semi-micro, semi-automated colorimetric assay for interferon. Journal of Laboratory and Clinical Medicine 89:1036–1042
    [Google Scholar]
  6. Colby C., Chamberlin M. J. 1969; The specificity of interferon induction in chick embryo cells by helical RNA. Proceedings of the National Academy of Sciences of the United States of America 63:160–167
    [Google Scholar]
  7. De Clercq E., De Somer P. 1972; Mechanism of the antiviral activity resulting from sequential administration of complementary homopolyribonucleotides to cell cultures. Journal of Virology 9:721–732
    [Google Scholar]
  8. Dianzani F., Cantagalli P., Gagnoni S., Rita G. 1968; Effect of DEAE-dextran on production of interferon induced by synthetic double-stranded RNA in L cell cultures. Proceedings of the Society for Experimental Biology and Medicine 128:708–710
    [Google Scholar]
  9. Dubes G. R., Klinger E. A. 1961; Facilitation of infection of monkey cells with poliovirus RNA. Science 133:99–100
    [Google Scholar]
  10. Finter N. B. 1969; Dye uptake methods for assessing viral cytopathogenicity and their application to interferon assays. Journal of General Virology 5:419–427
    [Google Scholar]
  11. Graham F. L., Vander Eb A. J. 1973; A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467
    [Google Scholar]
  12. Lampson G. P., Tytell A. A., Field A. K., Nemes M. M., Hilleman M. R. 1969; Influence of polyamines on induction of interferon and resistance to viruses by synthetic polynucleotides. Proceedings of the Society for Experimental Biology and Medicine 132:212–218
    [Google Scholar]
  13. Mccutchen J. H., Pagano J. S. 1968; Enhancement of the infectivity of SV40 DNA with DEAE-dextran. Journal of the National Cancer Institute 4:351–357
    [Google Scholar]
  14. Pitha P. M., Carter W. A. 1971; The Deae dextran:polyriboinosinate-polyribocytidylate complex. Physical properties and interferon induction. Virology 45:777–781
    [Google Scholar]
  15. Pitha P. M., Harper H. D., Pitha J. 1974; Dependence of interferon induction on cell membrane integrity. Virology 59:40–50
    [Google Scholar]
  16. Pitha P. M., Marshall L. W., Carter W. A. 1972; Interferon induction: rate of cellular attachment of poly IC. Journal of General Virology 15:89–92
    [Google Scholar]
  17. Smull C. E., Ludwig E. H. 1962; Enhancement of the plaque-forming capacity of poliovirus RNA with basic proteins. Journal of Bacteriology 84:1035–1040
    [Google Scholar]
  18. Tytell A. A., Field A. K. 1972; Interferons and host resistance with particular emphasis on induction by complex polynucleotides. CRC Critical Reviews in Biochemistry 1:1–32
    [Google Scholar]
  19. Vaheri A., Pagano J. S. 1965; Infectious poliovirus RNA: a sensitive method of assay. Virology 27:434–436
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-40-2-485
Loading
/content/journal/jgv/10.1099/0022-1317-40-2-485
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error