1887

Abstract

SUMMARY

Schmidt-Ruppin Rous sarcoma virus infected chick cells injected into newborn C3H/f mice gave rise to tumours at the site of inoculation. These tumours were transplantable in adult C3H/f mice and were able to induce tumours in the wing of adult Leghorn chickens. Tumour cells from the 18th passage in mice were used to establish a cell line in tissue culture (C3HSR). These cells released C-type virus particles that produced foci and were able to propagate in chick cells. Cloning of the C3HSR cells demonstrated that the same cell expressed both avian and murine antigens. Mouse cells infected with virus released by C3HSR cells produced murine leukaemia virus-like particles as revealed by the reverse XC syncytial test and by immunofluorescence tests.

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1978-07-01
2022-01-23
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References

  1. Aaronson S. A., Stephenson J. R. 1973; Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. Proceedings of the National Academy of Sciences of the United States of America 70:2055–2058
    [Google Scholar]
  2. Altaner C. A., Svec F. 1966; Virus production in rat tumors induced by chicken sarcoma virus. Journal of the National Cancer Institute 37:745–752
    [Google Scholar]
  3. Altaner C. A., Temin H. M. 1970; Carcinogenesis by RNA sarcoma viruses. XII. A quantitative study of infection of rat cells in vitro by avian sarcoma viruses. Virology 40:118–134
    [Google Scholar]
  4. Boettiger D. 1974a; Virogenic, nontransformed cells isolated following infection of normal rat kidney cells with B77 strain Rous sarcoma virus. Cell 3:71–76
    [Google Scholar]
  5. Boettiger D. 1974b; Activation and repression of virus expression in mammalian cells infected by Rous sarcoma virus. Cold Spring Harbor Symposium on Quantitative Biology 39:1169–1172
    [Google Scholar]
  6. Bolognesi D. P., Huper G., Green R. W., Graf T. 1974; Biochemical properties of oncornavirus polypeptides. Biochimica et Biophysica Acta 355:220–235
    [Google Scholar]
  7. Gelderblom H., Bauer H., Frank H. 1970; Investigation on virus production in RSV mammalian tumours. Journal of General Virology 7:33–45
    [Google Scholar]
  8. Hilgers J., Nowinski R. C., Geering G., Hardy W. 1972; Detection of avian and mammalian oncogenic RNA viruses (oncornaviruses) by immunofluorescence. Cancer Research 32:98–106
    [Google Scholar]
  9. Klement V., Rowe W. P., Hartley J. W., Pugh W. E. 1969; Mixed culture cytopathogenicity; a new test for growth of murine leukemia viruses in tissue culture. Proceedings of the National Academy of Sciences of the United States of America 63:753–758
    [Google Scholar]
  10. Kotler M. 1971; Interaction of avian sarcoma virus with rat embryo cells in cell culture. Journal of General Virology 12:199–206
    [Google Scholar]
  11. Kotler M., Weinberg E., Haspel O., Becker Y. 1972; Reverse transcriptase-containing particles induced in Rous sarcoma virus-transforming rat cells by arginine deprivation. Journal of Virology 10:439–446
    [Google Scholar]
  12. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193:265–275
    [Google Scholar]
  13. Lowry D. R., Rowe W. P., Teich N., Hartley J. W. 1971; Murine leukemia virus: high frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxy-uridine. Science 174:155–156
    [Google Scholar]
  14. Niwa O., Decleve A., Liberman M., Kaplan H. S. 1973; Adaptation of plaque assay methods to the in vitro quantitation of the radiation leukemia virus. Journal of Virology 12:68–73
    [Google Scholar]
  15. Rapp U. R., Nowinsky R. C. 1976; Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques. Journal of Virology 18:411–417
    [Google Scholar]
  16. Rowe W. P. 1972; Studies of genetic transmission of murine leukemia virus by AKR mice I. Cross with Fv-ln strain of mice. Journal of Experimental Medicine 136:1272–1285
    [Google Scholar]
  17. Rowe W. P., Hartley J. W. 1972; Studies of genetic transmission of murine leukemia virus by AKR: II. Crosses with Fv-1b strain of mice. Journal of Experimental Medicine 132:1286–1301
    [Google Scholar]
  18. Simkovic D. 1972; Characteristics of tumours induced in mammals, especially rodents by viruses of the avian leukosis sarcoma group. Advances in Virus Research 17:95–127
    [Google Scholar]
  19. Spiegelman S., Burny A., Das M. R., Keydar J., Schlom J., Travnicek M., Watson K. F. 1970; Characterisation of the products of RNA-directed DNA polymerases in oncogenic RNA viruses. Nature, London 227:563–567
    [Google Scholar]
  20. Spira G., Dreesman G. R., Melnick M. B., Kit S., Somers K. D. 1974; Expression of the major internal viral polypeptide in cells transformed by wild type and temperature sensitive murine sarcoma virus. Journal of Virology 14:1245–1252
    [Google Scholar]
  21. Stephenson J. R., Wilsnack R., Aaronson S. A. 1973; Segregation of loci for C-type virus induction in strain of mice with high and low incidence of leukaemia. Science 180:865–866
    [Google Scholar]
  22. Svec F., Hlavay E., Kossey P., Matoska J., Hladka M. 1974; Development of leukemia in rats with tumours induced by chicken sarcoma virus. Journal of the National Cancer Institute 52:31–33
    [Google Scholar]
  23. Varmus H. E., Vogt P. K., Bishop J. M. 1973; Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proceedings of the National Academy of Sciences of the United States of America 70:3067–3071
    [Google Scholar]
  24. Weiss R. A., Wong A. 1977; Phenotypic mixing between avian and mammalian RNA tumor viruses: 1. Envelope pseudotypes of Rous sarcoma virus. Virology 76:826–834
    [Google Scholar]
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