Two viruses of the herpes group, herpes simplex virus and pseudorabies virus, cause an increase in the activity of thymidine kinase (E.C. in baby hamster kidney cells (BHK 21) and primary rabbit kidney cells respectively (Klemperer 1967; Hamada, Kamiya & Kaplan, 1966). Klemperer (1967) showed that the thymidine kinase produced in cells infected with herpes simplex virus was inhibited by antiserum prepared against RK 13 cells (Beale, Christofinis & Furminger, 1963) infected with the same virus. Similar results were obtained by Hamada (1966) using thymidine kinase induced by pseudorabies virus and antiserum prepared against cells infected with pseudorabies virus.

Hamada (1966) suggested that the increased activity and altered serological properties of thymidine kinase might have been the result of allosteric alterations in the enzyme caused by environmental changes within the infected cell.


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