There are many reports of the requirements of DNA and RNA synthesis in the transformation of chick cells by Rous sarcoma virus (RSV) and other members of the avian leukosis group (Bather, 1963; Temin, 1963, 1964, 1964; Vigier & Goldé, 1964; Bader, 1964, 1965, 1965, 1966, 1966). These experiments suggest that functional host cell DNA is necessary for continued production of this RNA-containing virus. They also suggest that an important and sensitive DNA synthetic event is necessary early in the virus + cell interaction for infection and cell transformation to take place. These observations have led to the idea that the RNA of RSV interacts with, and produces changes in, the host DNA, leading to new genetic properties and to the formation of a DNA ‘provirus’ (Temin, 1964; Bader, 1965).

The mouse leukaemia viruses comprise a group similar in many respects to the avian leukosis group.


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