1887

Abstract

Summary

In cultures of mouse or chick embryo cells several non-steroidal anti-inflammatory drugs (salicylates, Ibufenac, phenylbutazone, Indomethacin, flufenamic and mefenamic acids, CI-583, and chloroquine) inhibit the multiplication of various viruses (encephalomyocarditis, Sindbis, influenza A2, Newcastle disease, herpes simplex and vaccinia). Two factors were critical for the virus inhibitory action of these drugs: the concentration of serum and the pH of the medium. The antiviral effect of these drugs seems to be due mainly to limitation of intracellular synthesis. However, salicylates and anthranilates also inhibit the adsorption and/or penetration of encephalomyocarditis virus into mouse cells.

The antiviral potency shows some correlation with other biochemical, cellular and clinical activities of these drugs.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-4-2-203
1969-03-01
2022-01-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/4/2/JV0040020203.html?itemId=/content/journal/jgv/10.1099/0022-1317-4-2-203&mimeType=html&fmt=ahah

References

  1. Barnardo D. E., Currey D. L. F., Mason R. M., Fox W. R., Wheatherall M. 1966; Mefenamic acid and flufenamic acid compared with aspirin and phenylbutazone in rheumatic arthritis. Br. med. J 2:342
    [Google Scholar]
  2. Cowey F. K., Whitehouse M. W. 1966; Biochemical properties of anti-inflammatory drugs. VII. Inhibition of proteolytic enzymes in connective tissue by chloroquine (Resochin) and related antimalarial (antirheumatic) drugs. Biochem. Pharmac. 15:1071
    [Google Scholar]
  3. Domenjoz R. 1966; Synthetic anti-inflammatory drugs: Concepts of their mode of action. Adv. Pharmacol 4145 Eds. S. Garattini and P. A. Shore New York and London: Academic Press;
    [Google Scholar]
  4. Hahn F. E., O’Brien R. L., Ciak J., Allison J. L., Olenick J. G. 1966; Studies on modes of action of chloroquine, quinacrine, and quinine and on chloroquine resistance. Milit. Med 131:1071 suppl 9
    [Google Scholar]
  5. Horvath S. 1954; A new sensitive method of the rolling drum type for influenza virus titration. Acta microbiol. hung 1:481
    [Google Scholar]
  6. Inglot A. D., Albin M. 1968; Inactivation of viruses by fenamic acids and related compounds. Life Sci (submitted for publication)
    [Google Scholar]
  7. Inglot A. D., Kochman M. 1966; Effect of choline salicylates and some other analogues of salicylic acid on the replication of EMC virus. in vitro. Experientia 22:322
    [Google Scholar]
  8. Inglot A. D., Wolna E. 1968; Reactions of non-steroidal anti-inflammatory drugs with the erythrocyte membrane. Biochem. Pharmac 17:269
    [Google Scholar]
  9. Inglot A. D., Kochman M., Mastalerz P. 1966; Activity of salicylates as inhibitors of virus replication in vitro and their mode of action. Acta virol 10:185
    [Google Scholar]
  10. Mallucci L. 1966; Effect of chloroquine on lysosomes and on growth of mouse hepatitis virus (MHV 3). Virology 28:355
    [Google Scholar]
  11. Skidmore I. F., Whitehouse M. W. 1967; Biochemical properties of anti-inflammatory drugs. X. Inhibition of serotonin formation in vitro and inhibition of the esterase activity of α-chymo-trypsin. Biochem. Pharmac 16:737
    [Google Scholar]
  12. Tamm I., Nemes M. M., Osterhout S. 1960; On the role of ribonucleic acid in animal virus synthesis. I. Studies with 5, 6-dichloro-1-β-d-ribofuranosylbenzimidazole. J. exp. Med 111:339
    [Google Scholar]
  13. Whitehouse M. W. 1965; Some biochemical and pharmacological properties of anti-inflammatory drugs. Fortschr. ArzneimittForsch 8:321
    [Google Scholar]
  14. Winter C. A. 1966; Non-steroidal anti-inflammatory agents. Fortschr. ArzneimittForsch 10:39
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-4-2-203
Loading
/content/journal/jgv/10.1099/0022-1317-4-2-203
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error