1887

Abstract

Summary

Heating adenovirus types 8 and 12 for 2 to 3 min. at 56° simultaneously reduced both interferon-inducting capacity and infectivity. In contrast, virus inactivated by u.v.-irradiation effectively stimulated interferon production in chick cells.

Chick cells infected with adenovirus type 12 and incubated at 25°, 35° or 40° produced about the same amount of interferon but the kinetics of interferon production differed, i.e. at the higher temperatures interferon formation commenced earlier.

The possibility that the penton antigen may be responsible for interferon induction by human adenoviruses in chick cells is discussed.

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1969-03-01
2021-10-28
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References

  1. Béládi I. 1962; Study on the plaque formation and some properties of the Aujeszky disease virus on chicken embryo cells. Acta vet. hung 12:417
    [Google Scholar]
  2. Béládi I., Pusztai R. 1967; Interferon-like substance produced in chick fibroblast cells inoculated with human adenoviruses. Z. Naturforsch 226:165
    [Google Scholar]
  3. Béládi I., Kahán A., Kukán E., Mucsi I., Pápai I. 1963; Aetiologic relationship of adenovirus type 8 to the epidemic of keratoconjunctivitis in Szeged. Acta microbial, hung 10:59
    [Google Scholar]
  4. Burke D. C., Isaacs A. 1958a; Further studies on interferon. Br. J. exp. Path 39:78
    [Google Scholar]
  5. Burke D. C., Isaacs A. 1958b; Some factors affecting the production of interferon. Br. J. exp. Path 39:452
    [Google Scholar]
  6. Everett S. F., Ginsberg H. S. 1958; A toxinlike material separable from type 5 adenovirus particles. Virology 6:770
    [Google Scholar]
  7. German A., Panouse-Perrin J., Quero A. M. 1968; Essais de production d’interferon par les cellules de l’embryon de poulet in ovo et in vitro sous l’influence du virus de la maladie de Newcastle vivant ou inactive. Ann. Inst. Pasteur 114:217
    [Google Scholar]
  8. Gifford G. E., Heller E. 1963; Effect of actinomycin D on interferon production by ‘active’ and ‘inactive’ Chikungunya virus in chick cells. Nature, Lond 200:50
    [Google Scholar]
  9. Glasgow L. A., Habel K. 1962; The role of interferon in vaccinia virus infection of mouse embryo tissue culture. J. exp. Med 115:503
    [Google Scholar]
  10. Hanna L., Jawetz E. 1962; Attempts to enhance infectivity of adenovirus type 8 for cell cultures. Proc. Soc. exp. Biol. Med 110:707
    [Google Scholar]
  11. Henle W., Henle G., Deinhardt F., Bergs V. 1959; Studies on persistent infections of tissue cultures. IV. Evidence for the production of an interferon in MCN cells by myxoviruses. J. exp. Med 110:525
    [Google Scholar]
  12. Ho M. 1964; Identification and ‘induction’ of interferon. Bact. Rev 28:367
    [Google Scholar]
  13. Ho M., Breinig M. K. 1962; Conditions for the production of an interferon appearing in chick cell cultures infected with Sindbis virus. J. Immun 89:177
    [Google Scholar]
  14. Ho M., Köhler K. 1967; Studies on human adenoviruses as inducers of interferon in chick cells. Arch. ges. Virusforsch 22:69
    [Google Scholar]
  15. Jawetz L., Hanna L., Nicholas A., Hoyt R. 1958; Some biological characteristics of adenovirus type 8. Am. J. Hyg 67:276
    [Google Scholar]
  16. Le Clerc J. L., Cogniaux-Le Clerc J. 1965; The production of interferon by two inactivated arboviruses. Acta virol., Prague 9:18
    [Google Scholar]
  17. Lockart R. Z. Jun 1963; Production of an interferon by L-cells infected with Western equine encephalomyelitis virus. J. Bact 85:556
    [Google Scholar]
  18. Macpherson I., Stoker M. 1962; Polyoma transformation of hamster cell clones–an investigation of genetic factors affecting cell competence. Virology 16:147
    [Google Scholar]
  19. Pereira H. G. 1958; A protein factor responsible for the early cytopathic effect of adenoviruses. Virology 6:601
    [Google Scholar]
  20. Porterfield J. S. 1959; A plaque technique for titration of Yellow fever virus and antisera. Trans. R. Soc. trop. Med. Hyg 53:458
    [Google Scholar]
  21. Reed L. J., Muench H. A. 1938; A simple method of estimating fifty per cent end-points. Am. J. Hyg 27:493
    [Google Scholar]
  22. Rowe W. P., Hartley J. W., Roizman B., Levy H. B. 1958; Characterization of a factor formed in the course of adenovirus infection of tissue cultures causing detachment of cells from glass. J. exp. Med 108:713
    [Google Scholar]
  23. Russell W. C., Valentine R. C., Pereira H. G. 1967; The effect of heat on the anatomy of the adenovirus. J. gen. Virol 1:509
    [Google Scholar]
  24. Stanček D. 1965; The role of interferon in tick-borne encephalitis virus-infected L-cells. III. The effects of temperature on the production of virus and interferon by L cells during acute and persistent infection. Acta virol 9:298
    [Google Scholar]
  25. Vilček J. 1961; Studies on an interferon from tick-borne encephalitis virus-infected cells (IF), I. Appearance of IF in infected chick embryo cell cultures. Acta virol., Prague 5:278
    [Google Scholar]
  26. Vilček J. 1963; Studies on an interferon from tick-borne encephalitis virus-infected cells. V. Failure of thermally inactivated virus to induce or to influence interferon formation. Acta virol., Prague 7:107
    [Google Scholar]
  27. Wagner R. R. 1963; Cellular resistance to viral infection, with particular reference to endogenous interferon. Bact. Rev 27:72
    [Google Scholar]
  28. Youngner J. S., Scott A. W., Hallum J. V., Stinebring W. R. 1966; Interferon production by inactivated Newcastle disease virus in cell cultures and in mice. J. Bact 92:862
    [Google Scholar]
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