1887

Abstract

SUMMARY

Lymphocytic choriomeningitis virus strain WE multiplied in cultivated peritoneal macrophages from unstimulated NMRI mice. As revealed by immunofluorescence technique, most cells participated in the infectious process. They were not, however, functionally altered. Morphologically, infected cells contained more cytoplasmic vacuoles, but these were also present, though less numerous, in uninfected ageing cells and in cells having phagocytosed Latex beads. As compared with the WE strain virus, the E-350 (Armstrong) strain multiplied more slowly to lower titres, but the proportion of infected cells was similar.

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1978-06-01
2022-01-23
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References

  1. Allison A. C. 1974; On the role of mononuclear phagocytes in immunity against viruses. Progress in Medical Virology 18:15–31
    [Google Scholar]
  2. Goldman R., Raz A. 1975; Concanavalin A and the in vitro induction in macrophages of vacuolation and a lysosomal enzyme synthesis. Experimental Cell Research 96:393–405
    [Google Scholar]
  3. Goud T. J. L. M., Schotte C., Van Furth R. 1975; Identification and characterization of the monoblast in mononuclear phagocyte colonies grown in vitro. Journal of Experimental Medicine 142:1180–1199
    [Google Scholar]
  4. Gschwender H. H., Rutter G., Lehmann-Grube F. 1976; Lymphocytic choriomeningitis virus. II. Characterization of extractable complement-fixing activity. Medical Microbiology and Immunology 162:119–131
    [Google Scholar]
  5. Hayashi M., Nakajima Y., Fishman W. H. 1964; The cytologic demonstration of β-glucuronidase employing naphthol AS-BI glucuronide and hexazonium pararosanilin; a preliminary report. Journal of Histochemistry and Cytochemistry 12:293–297
    [Google Scholar]
  6. Lehmann-Grube F., Ambrassat J. 1977; A new method to detect lymphocytic choriomeningitis virus-specific antibody in human sera. Journal of General Virology 37:85–92
    [Google Scholar]
  7. Lockart R. Z., Eagle H. 1959; Requirements for growth of single human cells. Science 129:252–254
    [Google Scholar]
  8. Löhler J., Ehlerding I., Lehmann-Grube F. 1974; Pathologie des lymphatischen Gewebes bei der Lymphozytaren Choriomeningitis der Maus. Zentralblatt für Bakteriologie und Hygiene, I. Abteilung Originate A 227:458–468
    [Google Scholar]
  9. Mims C. A. 1964a; Aspects of the pathogenesis of virus diseases. Bacteriological Reviews 28:30–71
    [Google Scholar]
  10. Mims C. A. 1964b; The peritoneal macrophages of mice. British Journal of Experimental Pathology 45:37–43
    [Google Scholar]
  11. Mims C. A., Subrahmanyan T. P. 1966; Immunofluorescence study of the mechanism of resistance to superinfection in mice carrying the lymphocytic choriomeningitis virus. Journal of Pathology and Bacteriology 91:403–415
    [Google Scholar]
  12. Mims C. A., Tosolini F. A. 1969; Pathogenesis of lesions in lymphoid tissue of mice infected with lymphocytic choriomeningitis (LCM) virus. British Journal of Experimental Pathology 50:584–592
    [Google Scholar]
  13. Popescu M., Lehmann-Grube F. 1977; Multiplication of lymphocytic choriomeningitis virus interfering particles in cell cultures and in mice. Perspectives in Virology (in the press)
    [Google Scholar]
  14. Popescu M., Schaefer K., Lehmann-Grube F. 1976; Homologous interference of lymphocytic chorio meningitis virus: detection and measurement of interference focus-forming units. Journal of Virology 20:1–8
    [Google Scholar]
  15. Rivers T. M., Scott T. F. M. 1936; Meningitis in man caused by a filterable virus. II. Identification of the etiological agent. Journal of Experimental Medicine 63:415–432
    [Google Scholar]
  16. Seamer J. 1965; Mouse macrophages as host cells for murine viruses. Archiv fiir die gesamte Virusforschung 17:654–663
    [Google Scholar]
  17. Stuart A. E., Habeshaw J. A., Davidson A. E. 1973; Phagocytes in vitro. In Handbook of Experimental Immunology 2nd edn vol 2 Cellular Immunology Edited by Weir D. M. Oxford: Blackwell Scientific Publications;
    [Google Scholar]
  18. Tosolini F. A., Mims C. A. 1971; Effect of murine strain and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses. Journal of Infectious Diseases 123:134–144
    [Google Scholar]
  19. Van Furth R., Cohn Z. A., Hirsch J. G., Humphrey J. H., Spector W. G., Langevoort H. L. 1972; The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bulletin of the World Health Organization 46:845–852
    [Google Scholar]
  20. Von Boehmer H., Lehmann-Grube F., Flemer R., Heuwinkel R. 1974; Multiplication of lymphocytic choriomeningitis virus in cultivated foetal inbred mouse cells and in neonatally infected inbred carrier mice. Journal of General Virology 25:219–228
    [Google Scholar]
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