1887

Abstract

SUMMARY

A previous paper (Kimberlin & Walker, 1977) described an experimental model of scrapie in hamsters in which the incubation period decreased progressively over the first 4 passages before becoming stable at the 5th and subsequent passes. Studies have been made of some of the agent strains present in brains taken from the 2nd, 3rd, 4th and 6th hamster passes. The results indicate the presence of at least two strains of agent at the 3rd passage level. One of these (431K) is highly pathogenic for mice and the other (263K) has an extremely low pathogenicity for mice. However only one of these strains (263K) is present in hamster brain after the 6th serial passage. It is suggested that the ‘adaptation’ of scrapie to hamsters may involve the selection, from a mixture, of a single strain which is highly pathogenic for hamsters. The possibility of modification of the properties of agent strains on passage discussed.

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1978-06-01
2022-08-18
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References

  1. Chandler R. L. 1963; Experimental scrapie in the mouse. Research in Veterinary Science 4:276–285
    [Google Scholar]
  2. Chandler R. L., Fisher J. 1963; Experimental transmission of scrapie to rats. Lancet ii:1165
    [Google Scholar]
  3. Chandler R. L., Turfrey B. A. 1972; Inoculation of voles, Chinese hamsters, gerbils and guinea pigs with scrapie brain material. Research in Veterinary Science 13:219–224
    [Google Scholar]
  4. Dickinson A. G. 1976 In Slow Virus Diseases of Animals and Man. Frontiers of Biology series vol 44 chapter 10 pp 209–241 Edited by Kimberlin R. H. Amsterdam and New York: North Holland;
    [Google Scholar]
  5. Dickinson A. G., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in mouse spleen. Journal of Comparative Pathology 79:363–366
    [Google Scholar]
  6. Dickinson A. G., Fraser H., Mcconnell I., Outran G. W., Sales D. I., Taylor D. M. 1975; Extraneural competition between different scrapie agents leading to loss of infectivity. Nature, London 253:556
    [Google Scholar]
  7. Dickinson A. G., Fraser H., Meikle V. M. H., Outram O. W. 1972; Competition between different scrapie agents in mice. Nature, New Biology 237:244–245
    [Google Scholar]
  8. Dickinson A. G., Meikle V. M. H. 1971; Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Molecular and General Genetics 112:73–79
    [Google Scholar]
  9. Dickinson A. G., Meikle V. M. H., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in the brain of mice. Journal of Comparative Pathology 79:15–22
    [Google Scholar]
  10. Fraser H. 1976 In Slow Virus Diseases of Animals and Man. Frontiers of Biology series vol 44 chapter 12 pp 267–305 Edited by Kimberlin R. H. Amsterdam and New York: North Holland;
    [Google Scholar]
  11. Eraser H., Dickinson A. G. 1968; The sequential development of the brain lesions of scrapie in three strains of mice. Journal of Comparative Pathology 78:301–311
    [Google Scholar]
  12. Kimberlin R. H., Millson G. C. 1976; The effects of cuprizone toxicity on the incubation period of scrapie in mice. Journal of Comparative Pathology 86:489–496
    [Google Scholar]
  13. Kimberlin R. H., Walker C. A. 1977; Characteristics of a short incubation model of scrapie in the golden hamster. Journal of General Virology 34:295–304
    [Google Scholar]
  14. Kimberlin R. H., Walker C. A., Millson G. C. 1975; Interspecies transmission of scrapie-like diseases. Lancet ii:1309–1310
    [Google Scholar]
  15. Pattison I. H., Jones K. M. 1968; Modification of a strain of mouse-adapted scrapie by passage through rats. Research in Veterinary Science 9:408–410
    [Google Scholar]
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