%0 Journal Article %A Avery, Roger J. %A Levy, Jay A. %T Relationship of Endogenous Murine Xenotropic Type C Virus Production to Spontaneous Transformation of Cultured Cells %D 1978 %J Journal of General Virology, %V 39 %N 3 %P 427-435 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-39-3-427 %I Microbiology Society, %X SUMMARY Spontaneous production of endogenous xenotropic viruses by clones of New Zealand Black (NZB) embryo cells occurs at a constant level even after several cell transfers. Foci of cell alteration occur spontaneously in some of the clonal lines after 6 to 10 passages. The amount of virus generated does not correlate with spontaneous transformation of these NZB cells nor of cells from NIH Swiss or BALB/c mice. The data demonstrate an intracellular regulation of xenotropic virus expression which remains stable over several cell generations and differs from that controlling cell transformation. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-39-3-427