1887

Abstract

SUMMARY

Leukaemia-resistant C57BL/6 mice inoculated with the Friend complex (FLC) present a transient but definite depression of the ability to develop IgM and IgG antibody-producing cells to sheep red cells (SRC). In this paper it is shown that this immunodepression cannot be attributed solely to the lymphatic leukaemia virus (LLV) component of FLC which is immunodepressive in susceptible mice. This conclusion was reached by investigating the immunological reactivity of C57BL/6 mice following inoculation with two isolates of LLV. Circumstantial evidence obtained by examining the replication of FLC and LLV, the antibody response to lipopolysaccharide (LPS) and the ability of syngeneic macrophages administered together with the antigen to restore the response to SRC points to the same conclusion. There were also indications that the low sensitivity to depression by viruses of the Friend complex exhibited by the anti-LPS antibody response is due to the mitogenic activity of this antigen.

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1978-05-01
2022-01-20
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References

  1. Andersson B., Blongren H. 1971; Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide. Cellular Immunology 2:411–418
    [Google Scholar]
  2. Axelrad A., Van Der Gaag H. C. 1968; Genetic and cellular basis of susceptibility or resistance to Friend leukaemia virus infection in mice. Proceedings of the Canadian Cancer Conference 8:313–343
    [Google Scholar]
  3. Bassin R. N., Tuttle N., Fischinger P. J. 1971; Rapid cell culture assay technique for murine leukaemia viruses. Nature, London 229:564–566
    [Google Scholar]
  4. Bendinelli M. 1971; Effect of Friend leukaemia virus and Rowson-Parr virus on immunological maturation of mice. Infection and Immunity 4:1–5
    [Google Scholar]
  5. Bendinelli M. 1973; Immunodepression by Rowson-Parr virus. In Virus Tumorigenesis and Immunogenesis pp 181–221 Edited by Ceglowski W. S., Friedman H. New York: Academic Press, Inc;
    [Google Scholar]
  6. Bendinelli M., Nardini L. 1973; Immunodepression by Rowson-Parr virus in mice. 1. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus. Infection and Immunity 7:I52–159
    [Google Scholar]
  7. Bendinelli M., Toniolo A., Friedman H. 1976; Reversal of immunosuppression induced by murine leukaemia viruses. Annals of the New York Academy of Sciences 276:431–441
    [Google Scholar]
  8. Carter R. L., Chesterman F. C., Rowson K. E. K., Salaman M. H., Wedderbdrn N. 1970; A new virus of minimal pathogenicity associated with Friend virus. II. Histological changes and immunodepressive effect. International Journal of Cancer 5:103–110
    [Google Scholar]
  9. Ceglowski W. S., Campbell B. P., Friedman H. 1975; Immunosuppression by leukaemia viruses. XI. Effect of Friend leukaemia virus on humoral immune competence of leukaemia-resistant C57BL/6 mice. Journal of Immunology 114:231–236
    [Google Scholar]
  10. Ceglowski W. S., Campbell B. P., Mortensen R. F., Friedman H. 1974; Humoral and cellular immune responses in susceptible and resistant strains of mice infected with Friend leukaemia virus. Proceedings of the Society for Experimental Biology and Medicine 146:619–624
    [Google Scholar]
  11. Hirano S., Ceglowski W. S., Allen J. L., Friedman H. 1969; Effect of Friend leukaemogenic virus on antibody-forming cells to a bacterial somatic antigen. Journal of the National Cancer Institute 43:1337–1345
    [Google Scholar]
  12. Klimar V., Bennett M., Eckner R. J. 1974; Mechanisms of genetic resistance to Friend virus leukaemia in mice. I. Role of 89Sr-sensitive effector cells responsible for rejection of bone marrow allografts. Journal of Experimental Medicine 139:1093–1109
    [Google Scholar]
  13. Kumar V., Caruso T., Bennett M. 1976; Mechanisms of genetic resistance to Friend virus leukaemia. III. Susceptibility of mitogen-responsive lymphocytes mediated by T cells. Journal of Experimental Medicine 143:728–740
    [Google Scholar]
  14. Lilly F., Pincus T. 1973; Genetic control of murine virus leukaemogenesis. Advances in Cancer Research 17:231–277
    [Google Scholar]
  15. Niwa M., Miller K. C., Rlbi E., Rudbach J. A. 1969; Alteration of physical, chemical and biological properties of endotoxin by treatment with mild alkali. Journal of Bacteriology 97:1069–1077
    [Google Scholar]
  16. Peled A., Haran-Ghera M. 1974; The cellular basis of immunosuppression caused by the radiation leukaemia virus. Immunology 26:323–329
    [Google Scholar]
  17. Poe W. J., Michael J. G. 1974; The lack of cellular cooperation in the immune response to E. coli 0127. Journal of Immunology 113:1033–1038
    [Google Scholar]
  18. Poe W. L., Michael J. G. 1976; Separation of the mitogenic and antigenic responses to bacterial lipopoly-saccharide. Immunology 30:241–248
    [Google Scholar]
  19. Roder J. C., Bell D. A., Singhal S. K. 1976; Cell interaction in B/W mice: a reversible defect at the T cell level. In Immune Reactivity of Lymphocytes: Development, Expression and Control pp 273–282 Edited by Feldman M., Globerson A. New York: Plenum Press;
    [Google Scholar]
  20. Roman J. M., Golub E. S. 1976; Leukaemia in AKR mice. I. Effects of leukaemic cells on antibodyforming potential of syngeneic and allogeneic normal cells. Journal of Experimental Medicine 143:482–496
    [Google Scholar]
  21. Rowson K. E. K., Parr I. 1970; A new virus of minimal pathogenicity associated with Friend virus. I.Isolation by end-point dilution. International Journal of Cancer 5:96–102
    [Google Scholar]
  22. Shearer G. M., Mozes E., Haran-Ghera N., Bentwich Z. 1973; Cellular analysis of immunosuppression to synthetic polypeptide immunogens induced by a murine leukaemia virus. Journal of Immunology no:736–741
    [Google Scholar]
  23. Schneider M., Dore J. F. 1969; Effet de l’injection d’un virus leucemogene murin (Friend) sur les reactions immunitaires de souris sensibles et resistantes a ce virus. Revue Frangaise d’Etudes Cliniques et Biologiques 14:1010–1014
    [Google Scholar]
  24. Steeves R. A., Eckner R. J. 1970; Host induced changes in infectivity of Friend spleen focus-forming virus. Journal of the National Cancer Institute 44:587–594
    [Google Scholar]
  25. Steeves R. A., Eckner R. J., Bennett M., Mirand E. A., Trudel P. J. 1971; Isolation and characterization of lymphatic leukaemia virus in the Friend virus complex. Journal of the National Cancer Institute 46:1209–1217
    [Google Scholar]
  26. Stutman O., Dupuy J. M. 1972; Resistance to Friend leukaemia virus in mice: effect of immunosuppression. Journal of the National Cancer Institute 49:1283–1293
    [Google Scholar]
  27. Von Eschen K. B., Rudbach J. A. 1976; Antibody responses of mice to alkaline detoxified lipopoly-saccharide. Journal of Immunology 116:8–11
    [Google Scholar]
  28. Watson J., Riblet R. 1974; Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides. Journal of Experimental Medicine 140:1147–1161
    [Google Scholar]
  29. Wedderburn N., Salaman M. H. 1968; The immunodepressive effect of Friend virus. II. Reduction of splenic haemolysin-producing cells in primary and secondary responses. Immunology 15:439–454
    [Google Scholar]
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