1887

Journal of General Virology header logo

Volume 38, Issue 1

Inter-relationship Between Genes Controlling Endogenous Virus Expression and those Controlling Susceptibility to Exogenous RNA Tumour Viruses: Evidence for Linkage Between the Group Specific Antigen and Tumour Virus Loci Free

Abstract

SUMMARY

A study using three inbred lines, Reaseheath C, HPRS-synthetic E and RPRL-7-2, was made to investigate the inter-relationship between the genes that regulate antigenic expression of the subgroup E endogenous virus and those that control susceptibility to infection with exogenous viruses of subgroups A, B and E.

It was found that the tumour virus () and group specific () antigen loci are linked, as indicated by the non-random association between the genes at the two loci. On the other hand, the genes at the other three loci, and , segregate and recombine at random in accordance with Mendel’s second law. That and are two independently segregating loci, was also confirmed in this study. Furthermore, the evidence that the locus, while segregating independently of the locus, is linked with the locus upheld the hypothesis of its existence contrary to the views of other workers. This study suggests that the locus could be used as a marker for the detection of the locus in chicken lines that lack the gene. Also, it has been shown that the gene is not identical to the gene contrary to our earlier hypothesis.

  • Received:
  • Accepted:
  • Published Online:
© Journal of General Virology 1977
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-38-1-61
1978-01-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/38/1/JV0380010061.html?itemId=/content/journal/jgv/10.1099/0022-1317-38-1-61&mimeType=html&fmt=ahah

References

  1. Calnek B. W., Payne L. N. 1976; Lack of correlation between Marek’s disease tumour induction and expression of endogenous avian RNA tumour virus genome. International Journal of Cancer 17:235–244
     [Google Scholar]
  2. Crittenden L. B., Stone H. A., Reamer R. H., Okazaki W. 1967; Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses. Virology 1:898–904
     [Google Scholar]
  3. Crittenden L. B., Wendel E. J., Motta J. V. 1973; Interaction of genes controlling resistance to RSV (RAV-O). Virology 52:373–384
     [Google Scholar]
  4. Crittenden L. B., Smith E. J., Weiss R. A., Sarma P. S. 1974; Host gene control of endogenous avian leukosis virus production. Virology 57:128–138
     [Google Scholar]
  5. Crittenden L. B., Motta J. V. 1975; The role of the tvb locus in genetic resistance to RSV(RAV-O). Virology 67:327–334
     [Google Scholar]
  6. Crittenden L. B., Robinson H. L. 1975; Genetic control of endogenous avian tumor virus expressions. In VHth International Symposium on Comparative Leukemia Research Copenhagen pp 146–150 Edited by Clemmesen J. Copenhagen, Yohn S. D. Columbus, Ohio: S. Karger;
     [Google Scholar]
  7. Crittenden L. B., Motta J. V., Smith E. J. 1977; Genetic control of RAV-O production in chickens. Virology 76:90–97
     [Google Scholar]
  8. Dougherty R. M., Di Stefano H. S. 1966; Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos. Virology 29:586–595
     [Google Scholar]
  9. Dren Cs. N., Pani P. K. 1977; Genetic control of resistance to subgroup A and subgroup C tumour viruses in Rhode Island Red fowl: evidence for linkage between the tumour virus a (tva) and tumour virus c (tve) loci. Journal of General Virology 35:13–23
     [Google Scholar]
  10. Hanafusa H., Hanafusa T., Miyamoto T. 1970; A cell associated factor essential for formation of an infectious form of Rous sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America 66:314–321
     [Google Scholar]
  11. Hanafusa T., Hanafusa H., Miyamoto T., Fleissner E. 1972; Existence and expression of tumor virus genes in chick embryo cells. Virology 47:475–482
     [Google Scholar]
  12. Kimball A. W. 1954; Short-cut formulas for the exact partition of x2 in contingency tables. Biometrics 10:452–458
     [Google Scholar]
  13. Mather K. 1951 In The measurement of linkage in heredity 2nd edition, ch IV pp 33–43 London: Methuen;
     [Google Scholar]
  14. Murphy H. 1977; A new replication-defective variant of the Bryan high-titre strain Rous sarcoma virus. Virology 77:705–721
     [Google Scholar]
  15. Pani P. K. 1974a; Studies in genetic resistance to RSV(RAV-O): a third type of genetic resistance typified by the W line of fowl and further support for the two loci genetic model. Journal of General Virology 23:33–40
     [Google Scholar]
  16. Pani P. K. 1974b; Close linkage between genetic loci controlling response of fowl to subgroup A and subgroup C sarcoma viruses. Journal of General Virology 22:187–195
     [Google Scholar]
  17. Pani P. K. 1975a; Genetic control of resistance of chick embryo cultures to RSV(RAV 5O). Journal of General Virology 27:163–172
     [Google Scholar]
  18. Pani P. K. 1975b; Genetic susceptibility of chicken x quail hybrid embryos to avian RNA tumour viruses. Journal of General Virology 28:159–163
     [Google Scholar]
  19. Pani P. K. 1976a; Genetics of resistance of fowl to infection by RNA tumour viruses. Proceedings of the Royal Society of Medicine 69:43–48
     [Google Scholar]
  20. Pani P. K. 1976b; Further studies in genetic resistance of fowl to RSV(RAV-O): evidence for interaction between independently segregating tumour virus 6 and tumour virus e genes. Journal of General Virology 32:441–453
     [Google Scholar]
  21. Pani P. K., Payne L. N. 1973; Further evidence for two loci which control susceptibility of fowl to RSV-(RAV-O). Journal of General Virology 19:235–244
     [Google Scholar]
  22. Payne L. N. 1972 In RNA Viruses and Host Genome in Oncogenesis pp 93–112 Edited by Emmelot P., Bentvelzen P. Amsterdam, London: North Holland Publishing Co;
     [Google Scholar]
  23. Payne L. N., Biggs P. M. 1966; Genetic basis of cellular susceptibility to the Schmidt-Ruppin and Harris strains of Rous sarcoma virus. Virology 29:190–198
     [Google Scholar]
  24. Payne L. N., Biggs P. M. 1970; Genetic resistance of fowl to MH2 reticuloendothelioma virus. Journal of General Virology 7:177–185
     [Google Scholar]
  25. Payne L. N., Chubb R. C. 1968; Studies on the nature and genetic control of an antigen in normal chick embryos which reacts in the COFAL test. Journal of General Virology 3:379–391
     [Google Scholar]
  26. Payne L. N., Pani P. K. 1971; Evidence for linkage between genetic loci controlling response of fowl to subgroup A and subgroup C sarcoma viruses. Journal of General Virology 13:253–259
     [Google Scholar]
  27. Payne L. N., Pani P. K., Weiss R. A. 1971; A dominant epistatic gene which inhibits cellular susceptibility to RSV(RAV-O). Journal of General Virology 13:455–462
     [Google Scholar]
  28. Rubin H. 1965; Genetic control of cellular susceptibility to pseudotypes of Rous sarcoma virus. Virology 26:270–276
     [Google Scholar]
  29. Sarma P. S., Turner R. C., Huebner J. R. 1964; An avian leukosis group-specific complement fixation reaction. Application for the detection and assay of non-cytopathogenic leukosis viruses. Virology 23:313–321
     [Google Scholar]
  30. Temin H. M., Rubin H. 1958; Characteristics of an assay to Rous sarcoma virus and Rous sarcoma cells in tissue culture. Virology 6:669–688
     [Google Scholar]
  31. Vogt P. K., Ishizaki R. 1965; Reciprocal patterns of genetic resistance to avian tumour viruses in two lines of chickens. Virology 26:664–672
     [Google Scholar]
  32. Vogt P. K., Ishizaki R., Duff R. 1967; Studies on the relationships among avian tumour viruses. In Sub Viral Carcinogenesis pp 207–310 Edited by Ito Y. Aichi Centre; Nagoya, Japan:
     [Google Scholar]
  33. Weiss R. A. 1969; The host range of bryan strain Rous sarcoma virus synthesized in the absence of helper virus. Journal of General Virology 5:511–528
     [Google Scholar]
  34. Weiss R. A., Payne L. N. 1971; The heritable nature of the factor in chicken cells which acts as a helper virus for Rous sarcoma virus. Virology 45:508–515
     [Google Scholar]
  35. Weiss R. A., Boettiger D., Love D. N. 1975; Phenotypic mixing between vesicular stomatitis virus and avian RNA tumor viruses. Cold Spring Harbor Symposia on Quantitative Biology 39:913–918
     [Google Scholar]
  36. Weiss R. A., Friis R. R., Katz E., Vogt P. K. 1971; Induction of avian tumour viruses in normal cells by physical and chemical carcinogens. Virology 46:920–938
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-38-1-61
Loading
Inter-relationship Between Genes Controlling Endogenous Virus Expression and those Controlling Susceptibility to Exogenous RNA Tumour Viruses: Evidence for Linkage Between the Group Specific Antigen and Tumour Virus e Loci
J. Gen. Virol. 38, 61 (1978); https://doi.org/10.1099/0022-1317-38-1-61
/content/journal/jgv/10.1099/0022-1317-38-1-61
/content/journal/jgv/10.1099/0022-1317-38-1-61
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error