Cultures of human fibroblasts trisomic for chromosome 21 were more sensitive to human leukocyte and human fibroblast interferons than were human diploid fibroblasts; these in turn were more sensitive than fibroblasts monosomic for chromosome 21. The sensitivities of these cells to human interferons correlated with the amounts of interferons which they bound. These data indicate that some gene on chromosome 21 codes for an interferon-receptor component.

Also, interferon from a heterologous species (mouse) was respectively much more and somewhat more active in trisomic and disomic cells than in monosomic cells. These data suggest that heterologous and homologous interferons may share common receptor component(s) coded by chromosome 21. Alternatively, human chromosome 21 may carry genetic information for some factor(s) responsible for increasing the exposure of certain surface receptors which are themselves coded by other chromosomes.


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