1887

Abstract

Summary

When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-37-2-419
1977-11-01
2022-12-09
Loading full text...

Full text loading...

/deliver/fulltext/jgv/37/2/JV0370020419.html?itemId=/content/journal/jgv/10.1099/0022-1317-37-2-419&mimeType=html&fmt=ahah

References

  1. Abdallah P. S., Mark J. B. D., Merigan J. C. 1976; Diagnosis of cytomegalovirus pneumonia in compromised hosts. The American Journal of Medicine 61:326–332
    [Google Scholar]
  2. Brodsky L., Rowe W. P. 1958; Chronic subclinical infection with mouse salivary gland virus. Proceedings of the Society for Experimental Biology and Medicine 99:654–655
    [Google Scholar]
  3. Gardner M. R., Officer J. E., Parker J., Estes J. D., Rongey R. W. 1974; Induction of disseminated virulent cytomegalovirus infection by immunosuppression of naturally chronically infected wild mice. Infection and Immunity 10:966–969
    [Google Scholar]
  4. Henson D., Smith R. D., Gehrke J. 1966; Non-fatal mouse cytomegalovirus hepatitis. American Journal of Pathology 49:871–880
    [Google Scholar]
  5. Hudson J. B., Misra V., Mosmann T. R. 1976; Cytomegalovirus infectivity: analysis of the phenomenon of centrifugal enhancement of infectivity. Virology 72:235–243
    [Google Scholar]
  6. Lang D. J. 1972; Cytomegalovirus infections in organ transplantation and post-transfusion. Archiv für die Gesamte Virusforschung 37:365–377
    [Google Scholar]
  7. Lang D. J., Cheung K. S., Schwartz J. N., Daniels C. A., Harwood S. E. 1976; Cytomegalovirus replication and the host immune response. Yale Journal of Biology and Medicine 49:45–48
    [Google Scholar]
  8. Mannini A., Medearis D. N. 1961; Mouse salivary gland virus infections. American Journal of Hygiene 73:329–343
    [Google Scholar]
  9. Medearis D. N. 1964; Mouse cytomegalovirus infection. II. Observations during prolonged infection. American Journal of Hygiene 80:103–112
    [Google Scholar]
  10. Meyers J. D., Spencer H. C., Watts J. C., Gregg M. B., Stewart J. A., Troupin R. H., Thomas E. D. 1975; Cytomegalovirus pneumonia after human marrow transplantation. Annals of Internal Medicine 82:181–188
    [Google Scholar]
  11. Olding L. B., Jensen F. C., Oldstone M. B. A. 1975; Pathogenesis of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction. Journal of Experimental Medicine 141:561–572
    [Google Scholar]
  12. Olding L. B., Kingsbury D. T., Oldstone M. B. A. 1976; Pathogenesis of cytomegalovirus infection. Distribution of viral products, immune complexes, and autoimmunity during latent murine infection. Journal of General Virology 33:267–280
    [Google Scholar]
  13. Osborn J. E., Walker D. L. 1968; Enhancement of infectivity of murine cytomegalovirus in vitro by centrifugal inoculation. Journal of Virology 2:853–858
    [Google Scholar]
  14. Osborn J. E., Walker D. L. 1970; Virulence and attentuation of murine cytomegalovirus. Infection and Immunity 3:228–236
    [Google Scholar]
  15. Prince A. M., Szmuness W., Millian S. J., David D. S. 1971; A serologic study of cytomegalovirus infection associated with blood transfusions. New England Journal of Medicine 284:1125–1131
    [Google Scholar]
  16. Rifkind D., Goodman N., Hill R. B. 1967; The clinical significance of cytomegalovirus infection in renal transplant recipients. Annals of Internal Medicine 66:1116–1128
    [Google Scholar]
  17. Selgrade M. K., Osborn J. E. 1974; Role of macrophages in resistance to murine cytomegalovirus. Infection and Immunity 10:1383–1390
    [Google Scholar]
  18. Stevens J. G. 1977; Latent characteristics of selected herpesviruses. Advances in Cancer Research (in the press)
    [Google Scholar]
  19. Weller T. H. 1971; The cytomegaloviruses: ubiquitous agents with protein clinical manifestations. New England Journal of Medicine 285:203 267–274
    [Google Scholar]
  20. Wu B. C., Dowling J. N., Armstrong J. A., Ho M. 1975; Enhancement of mouse cytomegalovirus infection during host-versus-graft reaction. Science 190:56–58
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-37-2-419
Loading
/content/journal/jgv/10.1099/0022-1317-37-2-419
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error