1887

Abstract

Summary

The effect of mouse interferon (ITF) on the expression of Friend leukaemia virus (FLV) and on dimethyl sulphoxide (DMSO)-stimulated haemoglobin synthesis in Friend erythroleukaemic cells (FLC) was studied. Immunofluorescent staining was used to detect intracellular antigens, and incorporation of H-uridine into virions to detect extracellular virus release. Interferon markedly inhibited haemoglobin synthesis and FLV production, but enhanced accumulation of virus antigens in the cytoplasm; on the cell surface, however, FLV antigens were present to the same extent whether ITF was present or not. When ITF was removed, virus production rose and intracellular virus antigens fell to the levels of untreated controls.

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1977-11-01
2024-12-13
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References

  1. Bernini L. F. 1969; Rapid estimation of haemoglobin A2 by DEAE chromatography. Biochemical Genetics 2:305–310
    [Google Scholar]
  2. Billiau A., Edy V. G., Sobis H., De Somer P. 1974; Influence of interferon on virus-particle synthesis in on cornavirus-carrier lines. II. Evidence for a direct effect on particle release. International Journal of Cancer 14:335–340
    [Google Scholar]
  3. Billiau A., Heremans H., Allen P. T., De Maeyer–Guignard J., De Somer P. 1976; Trapping of OnCOrnavirus particles at the surface of interferon–treated cells. Virology 73:537–542
    [Google Scholar]
  4. Billiau A., Sobis H., De Somer P. 1973; Influence of interferon on virus particle formation in different oncornavirus carrier cell lines. International Journal of Cancer 12:646–653
    [Google Scholar]
  5. Chany C., Vignal M. 1970; Effect of prolonged interferon treatment on mouse embryonic fibroblasts transformed by murine sarcoma virus. Journal of General Virology 7:203–210
    [Google Scholar]
  6. Dulbecco R., Freeman G. 1959; Plaque production by the Polyoma virus. Virology 8:396–397
    [Google Scholar]
  7. Fitzgerald G. R. 1969; The effect of interferon on focus formation and yield of murine sarcoma virus in vitro. Proceedings of the Society for Experimental Biology and Medicine 130:960–965
    [Google Scholar]
  8. Friedman R. M., Chang E. M., Ramseur J. M., Meyers M. W. 1975; Interferon–directed inhibition of chronic murine leukemia virus production in cell cultures: lack of effect on intracellular viral markers. Journal of Virology 16:569–574
    [Google Scholar]
  9. Friedman R. M., Costa J. C., Ramseur J. M., Meyers M. W., Jay F. T., Chany E. H. 1976; Persistance of the viral genome in interferon–treated cells infected with oncogenic or non–oncogenic viruses. Journal of Infectious Diseases 133:A43–A50
    [Google Scholar]
  10. Friedman R. M., Ramseur J. M. 1974; Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon. Proceedings of the National Academy of Sciences of the United States of America 71:3542–3544
    [Google Scholar]
  11. Friend C., Patuleia M. C., De Harven E. 1966; Erythrocytic maturation in vitro of murine (Friend) virus–induced leukemia cells. National Cancer Institute Monographs 22:505–522
    [Google Scholar]
  12. Friend C., Scher W., Holland G. J., Sato T. 1971; Hemoglobin synthesis in murine virus–induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proceedings of the National Academy of Sciences of the United States of America 68:378–382
    [Google Scholar]
  13. Gresser I., Coppey J., Fontaine–Brouty–Boye D., Falcoff R. 1967; Interferon and murine leukemia. Efficacy of interferon preparations administered after inoculation of Friend virus. Nature, London 215:174–175
    [Google Scholar]
  14. Joklik W. K., Merigan T. C. 1966; Concerning the mechanism of action of interferon. Proceedings of the National Academy of Sciences of the United States of America 56:558–565
    [Google Scholar]
  15. Jungwirth C., Horak I., Bodo G., Lindner J., Schultze B. 1972; The synthesis of poxvirus specific RNA in interferon treated cells. Virology 48:59–70
    [Google Scholar]
  16. Levy J., Terada M., Rifkind R. A., Marks P. A. 1975; Induction of erythroid differentiation by dimethyl sulfoxide in cells infected with Friend virus. Relationship to the cell cycle. Proceedings of the National Academy of Sciences of the United States of America 72:28–32
    [Google Scholar]
  17. Lieberman D., Voloch Z., Aviv H., Nudel V., Revel M. 1975; Effects of interferon on hemoglobin synthesis and leukemia virus production in Friend cells. Molecular Biology Reports 1:477–481
    [Google Scholar]
  18. Lindahl P., Leary P., Gresser I. 1972; Enhancement by interferon of specific cytotoxicity of sensitized lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 69:721–725
    [Google Scholar]
  19. Lindahl P., Gresser I., Leary P., Tovey M. 1976; Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proceedings of the National Academy of Sciences of the United States of America 73:1284–1287
    [Google Scholar]
  20. Matarese G. P., Rossi G. B. 1977; Effect of interferon on growth and division cycle of Friend erythro– leukemic murine cells in vitro. Journal of Cell Biology 75: (in the press)
    [Google Scholar]
  21. Mcclintock P. R., Papaconstantinou J. 1974; Regulation of hemoglobin synthesis in a murine erythroblastic leukemia cell: the requirement for replication to induce hemoglobin synthesis. Proceedings of the National Academy of Sciences of the United States of America 71:4551–4555
    [Google Scholar]
  22. Metz D. H., Esteban J. 1972; Interferon inhibits viral protein synthesis in L cells infected with vaccinia virus. Nature, London 238:385–388
    [Google Scholar]
  23. Orkin S. H., Harosi F. I., Leder P. 1975; Differentiation in erythroleukemic cells and their somatic hybrids. Proccedings of the National Academy of Sciences of the United States of America 72:98–102
    [Google Scholar]
  24. Ostertag W., Cole T., Crozier T., Gaedicke G., Kind J., Kluge N., Krieg J., Roesler G., Steinheider G., Weimann B., Dube S. 1974; Viral involvement in the differentiation of erythroleukemia mouse and human cells. In Differentiation and Control of Malignancy of Tumor Cells pp 493–521 Edited by Nakahara W., Ono F., Sugimura T., Sugano H. Baltimore: University Park Press;
    [Google Scholar]
  25. Panem S., Kirsten W. H. 1973; Release of mouse leukemiasarcoma virus from synchronized cells. Journal of the National Cancer Institute 50:563–566
    [Google Scholar]
  26. Peries J., Canivet M., Guillemain B., Boiron M. 1968; Inhibitory effect of interferon preparations on the development of foci of altered cells induced in vitro by mouse sarcoma virus. Journal of General Virology 3:465–468
    [Google Scholar]
  27. Pitha P. M., Rowe W. P., Oxman M. N. 1976; Effect of interferon on exogenous, endogenous, and chronic murine leukemia virus infection. Virology 70:324–338
    [Google Scholar]
  28. Rossi G. B., Matarese G. P., Grappelli C., Belardelli F., Benedetto A. 1977a; Inhibition by interferon of dimethyl sulfoxide–induced erythroid differentiation of Friend leukemia cells. Nature, London 267:50–51
    [Google Scholar]
  29. Rossi G. B., Dolei A., CIoé L., Benedetto A., Matarese G. P., Belardelli F. 1977b; Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide–stimulated Friend erythroleukemic cells treated with interferon. Proceedings of the National Academy of Sciences of the United States of America 74:2036–2040
    [Google Scholar]
  30. Rossi-Fanelli A., Antonini E., Caputo A. 1958; Studies on the structure of hemoglobin. I. Physicochemical properties of human globin. Biochimica et Biophysica Acta 30:608–615
    [Google Scholar]
  31. Sarma P. S., Shiu G., Baron S., Huebner R. J. 1969; Inhibitory effect of interferon on murine sarcoma and leukemia virus infection in vitro. Nature, London 223:845–846
    [Google Scholar]
  32. Sato T., Friend C., De Harven E. 1971; Ultrastructural changes in Friend erythroleukemia cells treated with dimethyl sulphoxide. Cancer Research 31:1402–1417
    [Google Scholar]
  33. Stewart W. E., Gosser L. B., Lockart R. Z. >Jun 1971; Priming: a non–antiviral function of interferon. Journal of Virology 7:792–801
    [Google Scholar]
  34. Stewart W. E., De Clercq E., Billiau A., Desmyter J., De Somer P. 1972; Increased susceptibility of cells treated with interferon to the toxicity of poly (I:C). Proceedings of the National Academy of Sciences of the United States of America 69:1851–1854
    [Google Scholar]
  35. Swetly P., Ostertag W. 1974; Friend virus release and induction of haemoglobin synthesis in erythro– leukaemic cells respond differently to interferon. Nature, London 251:642–644
    [Google Scholar]
  36. Swetly P. 1976; Induction of interferon and erythropoietic differentiation in cells transformed by Friend virus. Journal of Virology 17:27–32
    [Google Scholar]
  37. Taylor J. 1965; Studies on the mechanism of action of interferon. Interferon action and RNA synthesis in chick embryo fibroblasts infected with Semliki Forest virus. Virology 25:340–349
    [Google Scholar]
  38. Turner W., Chan S. P., Chirigos A. 1970; Stimulation of humoral and cellular antibody formation in mice by poly I:C. Proceedings of the Society for Experimental Biology and Medicine 133:334–338
    [Google Scholar]
  39. Wayne Wiens A., Mcclintock P. R., Papaconstantinou I. 1976; The dependence of erythroid differentiation on cell replication in dimethyl sulfoxide-treated Friend leukemia-virus-infected cells. Biochemical and Biophysical Research Communications 70:824–831
    [Google Scholar]
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