Sendai and measles viruses were tested for their interferon-inducing capacity in human lymphoblast cells. Sendai virus reproducibly induced considerable amounts of interferon (1 research reference interferon unit/103 cells), but no increase in infectious virus titre was observed. Two Edmonston–Enders strains of measles virus grew very well. The attenuated (A) strain was a good interferon inducer (4 units/103 cells), while the virulent (V) strain induced only minimal amounts at a high multiplicity of infection. Pre-treatment of the cells with 5-iododeoxyuridine (IdUrd) had no effect on the growth of Sendai or EE measles virus and on interferon yields induced by Sendai virus. It slightly potentiated interferon induction by EE measles virus. Partial u.v.-light-inactivation of Sendai virus infectivity resulted in a parallel loss in interferon-inducing capacity.
AdamsA.,
LidinB.,
StranderH.,
CantellK.1975; Spontaneous interferon production and Epstein-Barr virus antigen expression in human lymphoid cell lines. Journal of General Virology 28:219–223
BilliauA.,
JoniauM.,
De SomerP.1972; Production of crude human interferon with high specific activity. Proceedings of the Society for Experimental Biology and Medicine 140:485–491
De MaeyerE.,
EndersJ.F.1965; Growth characteristics, interferon production and plaque formation with different lines of Edmonston measles virus. Archiv für die gesamte Virusforschung 16:151–160
HaaseA. T.,
JohnsonJ. S.,
KaselJ. A.,
MargolisS.,
LevyH. B.1970; Induction of interferon in lymphoblastoid cell lines. Proceedings of the Society for Experimental Biology and Medicine 133:1076–1083