Two morphological types of human rotavirus particles were separated in caesium chloride density gradients. The particles of higher density (‘incomplete’ particles without an outer capsid layer) banded at a density of 1.38 g/ml, while the less dense (‘complete’ particles with an outer as well as an inner capsid layer) banded at a density of 1.36 g/ml. Some particles were found with an incomplete outer layer of capsomeres. The particle/infectivity ratio for tissue cultures of the fraction containing complete particles was more than 3 log higher than that of the fraction containing incomplete particles. But, as there was a small number of complete particles in the fraction containing mostly incomplete particles, it was impossible to determine whether the incomplete particles had a low infectivity or whether they had none at all.


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