Fibroblast interferon may be stabilized against many inactivating influences by the addition of certain simple sulphydryl reagents. The use of such easily removable and relatively non-toxic stabilizers should help in the preparation and purification of fibroblast interferon for clinical use.
DavidsonB. E.,
HirdF. J. R.1967; The reactivity of the disulphide bonds of purified proteins in relationship to primary structure. Biochemical Journal 104:473–479
De SomerP.,
JoniauM.,
EdyV. G.,
BilliauA.1973; Mass production of human interferon in diploid cells. Proceedings of the Tissue Culture Association Workshop Lake Placid May 1973 39–46
EdyV. G.,
BilliauA.,
JoniauM.,
De SomerP.1974; Stabilisation of human and mouse interferons towards shaking and guanidine hydrochloride by acid pH. Proceedings of the Society for Experimental Biology and Medicine 146:249–253