A Mouse Model for Post-Exposure Rabies Prophylaxis: The Comparative Efficacy of Two Vaccines and of Antiserum Administration Free

Abstract

SUMMARY

Mice challenged with rabies virus were vaccinated 24 h later with one of two types of rabies vaccine. Vaccine prepared from a BHK cell substrate resulted in the production of serum interferon and neutralizing antibody, whereas vaccine prepared from a human diploid cell substrate gave rise to neutralizing antibody but no interferon. Only the first vaccine was effective in reducing mortality.

Various combinations of mouse hyperimmune antiserum, purified IgG, complement and RNase were administered to other groups of mice challenged with rabies, but these had no significant effect on their survival.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-36-1-51
1977-07-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/36/1/JV0360010051.html?itemId=/content/journal/jgv/10.1099/0022-1317-36-1-51&mimeType=html&fmt=ahah

References

  1. Abelseth M. K. 1964; An attenuated rabies vaccine for domestic animals produced in tissue culture. Canadian Veterinary Journal 5:279–286
    [Google Scholar]
  2. Abelseth M. K. 1966; The growth of rabies virus in tissue culture and its use as a living attenuated vaccine for domestic animals. Ph.D Thesis University of Minnesota;
    [Google Scholar]
  3. Atanasiu P., Bahmanyar M., Baltazard M., Fox J. P., HabeL K., Kaplan M. M., Kissling R. E., Komarov A., Koprowski H., Lepine P., Perez Gallardo F., Schaeffer M. 1957; Rabies neutralizing antibody response to different schedules of serum and vaccine inoculations in non-exposed persons: part II. Bulletin of the World Health Organization 17:911–932
    [Google Scholar]
  4. Baer G. M., Cleary W. F. 1972; A model in mice for the pathogenesis and treatment of rabies. Journal of Infectious Diseases 125:520–527
    [Google Scholar]
  5. Cabasso V. J., Dobktn M. B., Roby R. E., Hammar H. 1974; Antibody response to a human diploid cell rabies vaccine. Applied Microbiology 27:553–561
    [Google Scholar]
  6. Clark F., Wiktor T., Koprowski H. 1975; Human vaccines, past and present. In The Natural History of Rabies vol I pp 341–365 Edited by Baer G. M. New York: Academic Press;
    [Google Scholar]
  7. Dean D. J., Sherman I. 1962; Potency of commercial rabies vaccine used in wan. Public Health Reports 77:705–710
    [Google Scholar]
  8. Dean D. J., Evans W. M., Thompson W. R. 1964; Studies on the LEP Flury strain of modified live rabies virus produced in embryonating chicken eggs and tissue culture. American Journal of Veterinary Research 25:756–763
    [Google Scholar]
  9. Ercegovac D. T. 1956; Ergebnisse experimenteller Arbeiten auf dem Gebiet der Tollwutprophylaxe. Wiener Tierdrztliche Monatsschrift 43:288–306
    [Google Scholar]
  10. Fenje P., Postic B. 1970; Protection of rabbits against experimental rabies by poly I. poly C. Nature, London 226:171–172
    [Google Scholar]
  11. Fenje P., Postic B. 1971; Prophylaxis of experimental rabies with the polyriboinosinic-polyribocytidylic acid complex (poly I:C). Journal of Infectious Diseases 125:520–527
    [Google Scholar]
  12. Fischer W. D., Kanning R. E. 1968; Isolation and characterization of rat macrophage. National Cancer Institute Monographs 21:463
    [Google Scholar]
  13. Fuenzalida E. 1972; Human pre-exposure rabies immunization with suckling mouse brain vaccine. Bulletin of the World Health Organization 46:561–563
    [Google Scholar]
  14. Goldwasser R. A., Kissling R. E. 1958; Fluorescent antibody staining of street and fixed rabies virus antigens. Proceedings of the Society for Experimental Biology and Medicine 98:219–223
    [Google Scholar]
  15. Greenwood M. 1945/46; Tenth report on data of anti-rabies treatment supplied by Pasteur Institutes. Bulletin of the World Health Organization of the League of Nations 12:301
    [Google Scholar]
  16. Harmon M. W., Janis B. 1975; Therapy of murine rabies after exposure: efficacy of polyriboinosinic-polyribocytidylic acid alone and in combination with three rabies vaccines. Journal of Infectious Diseases 132:241–249
    [Google Scholar]
  17. Janis B., Habel K. 1972; Rabies in rabbits and mice: the protective effect of polyriboinosinic polyribo-cytidylic acid. Journal of Infectious Diseases 175:345–352
    [Google Scholar]
  18. Janis B., Harmon M. W. 1974; The protective effect of interferon in street rabies virus infected mice. Abstracts of the Annual Meeting of the American Society for Microbiology p 262
    [Google Scholar]
  19. Koprowski H., Van Der Scheer J., Black J. 1950; Use of hyperimmune antirabies serum concentrates in experimental rabies. American Journal of Medicine 8:412–420
    [Google Scholar]
  20. Levy H. B., Baer G., Baron S., Gibbs C. F., Iadarola M., London W., Rice J. M. 1974; Induction of interferon in non-human primates by a nuclease-resistance polyriboinosinic. polyribocytidylic acid complex. IRCS (Research on: Biochemistry; Immunology and Allergy; Microbiology, Parasitology and Infectious Diseases; Pharmacology) 2:1643
    [Google Scholar]
  21. Macpherson I., Stoker M. 1962; Polyoma transformation of hamster cell clones. An investigation of genetic factors affecting cell competence. Virology 16:147–151
    [Google Scholar]
  22. Mancini G., Carbono A. P., Hermens J. F. 1963; Immunochemical quantitation of antigens by simple radial immunodiffusion. Investigating Chemistry 2:235
    [Google Scholar]
  23. Markowski S., Legezynski S. 1929; Recherches experimentales sur la vaccination antirabique curative des chiens. Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 100:289–290
    [Google Scholar]
  24. Mckendrick A. G. 1940; A ninth analytical review of reports from Pasteur Institutes on the results of anti-rabies treatment. Bulletin of the World Health Organization of the League of Nations 9:31
    [Google Scholar]
  25. Mikhailovsky E. M., Tsiang H., Atanasiu P. 1971; Concentration du virus rabique par le polyethylene glycol. Annales de L’ Institut Pasteur (Paris) 121:563–568
    [Google Scholar]
  26. Murphy F. A., Bauer S. P. 1974; Early street rabies virus infection in striated muscle and later progression to the central nervous system. Intervirology 3:256–268
    [Google Scholar]
  27. Murphy F. A., Bauer S. P., Harrison A. K., Winn W. C. Jun 1973; Comparative pathogenesis of rabies and rabies-like viruses. Viral infection and transit from inoculation site to the central nervous system. Laboratory Investigation 28:361–376
    [Google Scholar]
  28. Obijeski J. F., Marchenko A. T., Bishop D. H. L., Cann B. W., Murphy F. A. 1974; Comparative electro’ phoretic analysis of the virus proteins of four rhabdoviruses. Journal of General Virology 22:21–33
    [Google Scholar]
  29. Oroszlan S., Gilden R. V. 1970; Immune virolysis: effect of antibody and complement on C-type RNA virus. Science 168:1478–1480
    [Google Scholar]
  30. Otten L. 1947; Investigation into rabies. II. Antonie van Leeuwenhoek Journal of Microbiology and Serology 13:101–127
    [Google Scholar]
  31. Proca G., Bobes S. 1940; Anti-rabic immunization: living vaccines and killed vaccines. Bulletin of the World Health Organisation of the League of Nations 9:79–130
    [Google Scholar]
  32. Sikes R. K., Peacock G. V., Acha P., Arko R. J., Dierks R. 1971a; Rabies vaccines: duration-of-immunity study in dogs. Journal of the American Veterinary Medical Association 159:1491–1499
    [Google Scholar]
  33. Sikes R. K., Cleary W. F., Koprowski H., Wiktor T. J., Kaplan M. M. 1971b; Effective protection of monkeys against death from street virus by post-exposure administration of tissue-culture rabies vaccine. Bulletin of the World Health Organisation 45:1–11
    [Google Scholar]
  34. Smith J. S., Yager P. A., Baer G. M. 1973; A rapid reproducible test for determining rabies neutralizing antibody. Bulletin of the World Health Organisation 48:535–541
    [Google Scholar]
  35. Stone S. H. 1954; Method for obtaining venous blood from the orbital sinus of the rat or mouse. Science 119:100
    [Google Scholar]
  36. Weeke-Luttmann M. 1970; Steigerung der neutralisation von Vaccinia-Virus durch Antiglobulin. Archiv fur die Gesamte Virusforschung 31:28–32
    [Google Scholar]
  37. Wiktor T. J., Sokol F., Kuwert E., Koprowski H. 1969; Immuno-genicity of concentrated and purified rabies vaccine of tissue culture origin. Proceedings of the Society for Experimental Biology and Medicine 131:799–805
    [Google Scholar]
  38. Wiktor T. J., Lerner R. A., Koprowski H. 1971; Inhibitory effect of passive antibody on active immunity induced against rabies by vaccination. Bulletin of the World Health Organization 45:747–753
    [Google Scholar]
  39. Wiktor T. J., Plotkin S. A., Grella D. W. 1973; Human cell culture rabies vaccine. Journal of the American Medical Association 224:1170–1171
    [Google Scholar]
  40. Wiktor T. J., Postic B., Ho M., Koprowski H. 1972; Role of interferon induction in the protective activity of rabies vaccines. Journal of Infectious Diseases 126:408–418
    [Google Scholar]
  41. Winkler W. G., Schmidt R. C., Sikes R. K. 1969; Evaluation of human rabies immune globulin and homologous and heterologous antibody. Journal of Immunology 102:1314–1321
    [Google Scholar]
  42. World Health Organization, Expert Committee on Rabies, Sixth Report 1973 Technical Report Series No 523 pp 50–51 Geneva, Switzerland: WHO;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-36-1-51
Loading
/content/journal/jgv/10.1099/0022-1317-36-1-51
Loading

Data & Media loading...

Most cited Most Cited RSS feed