Antiviral Activity in the Rabbit Cornea of Adenine Arabinoside, Ara-A 5′ Monophosphate, and Hypoxanthine Arabinoside; and Interactions with Adenosine Deaminase Inhibitor Free

Abstract

SUMMARY

The multiple microtrephination technique was used in the rabbit cornea to compare the activity against herpes simplex virus (HSV) of adenine arabinoside (ara-A), ara-A 5′ monophosphate (ara-AMP) and hypoxanthine arabinoside (ara-Hx), and to determine the effect of addition of adenosine deaminase inhibitor (ADAI) to each. The greatest antiviral activity was shown by ara-AMP, and the least by ara-Hx. ADAI increased the activity of ara-A but had no effect on ara-AMP or ara-Hx.

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/content/journal/jgv/10.1099/0022-1317-36-1-199
1977-07-01
2024-03-29
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References

  1. Connor J. D., Sweetman L., Carey S., Stuckey M. A., Buchanan R. A. 1974; Antiviral activity in vitro of adenine arabinoside for vaccinia virus. Antibiotics and Antimicrobial Chemotherapy 6:630–636
    [Google Scholar]
  2. De Garilhe M. P., De Rudder J. 1964; Effét de deux nucleosides de l’arabinoside sur la multiplication des virus de l’herpes et de la vaccine en culture cellulaire. Compte Rendu de l’Academie des Sciences(Paris) 259:2725–2728
    [Google Scholar]
  3. Jones B. R., AL-Hussaini M. 1963; Therapeutic considerations in ocular vaccinia. Transactions of the Opthalmological Society of the United Kingdom 83:613–631
    [Google Scholar]
  4. Jones B. R., Mcgill J. I., Mckinnon J. R., Holt-Wilson A. D., Williams H. P. 1975 In Adenine arabinoside: an Antiviral Agent 1st ed pp 411–416 Edited by Pavan-Langston D., Buchanan R. A., Alford C. A. New York: Raven Press;
    [Google Scholar]
  5. Jones B. R., Patterson A. 1967; Anti-inflammatory drugs and infectious disease: effects of antinflammatory drugs on virus replication in the cornea. Excerpta Medica International Congress series no 163:143–157
    [Google Scholar]
  6. McGill J. I., Coster D. J., Fraunfelder F. T., Holt-Wilson A. D., Williams H. P., Jones B. R. 1975; The use of adenine arabinoside in the management of herpetic keratitis. Transactions of the Ophthalmological Society of the United Kingdom 95:246–249
    [Google Scholar]
  7. Miller F. A., Dixon G. J., Ehrlich J., Sloan B. R. Jun, Mclean I. W. 1968; Antiviral activity of 9-β-D-arabinofuranosyladenine. I. Cell culture studies. Antimicrobial Agents and Chemotherapy 8:136–147
    [Google Scholar]
  8. Pavan-Langston D., Langston R. H. S., Geary P. A. 1974; Prophylaxis and therapy of experimental ocular herpes simplex. Archives of Opthalmology 92:417–421
    [Google Scholar]
  9. Reed L. J., Muench H. 1938; Simple method of estimating 50 percent endpoints. American Journal of Hygiene 27:493–495
    [Google Scholar]
  10. Schabel F. M. Jun 1968; The antiviral activity of 9-β-arabinofuranosyl adenine (ara-A). Chemotherapy 13:321–338
    [Google Scholar]
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