1887

Abstract

SUMMARY

The multiple microtrephination technique was used in the rabbit cornea to compare the activity against herpes simplex virus (HSV) of adenine arabinoside (ara-A), ara-A 5′ monophosphate (ara-AMP) and hypoxanthine arabinoside (ara-Hx), and to determine the effect of addition of adenosine deaminase inhibitor (ADAI) to each. The greatest antiviral activity was shown by ara-AMP, and the least by ara-Hx. ADAI increased the activity of ara-A but had no effect on ara-AMP or ara-Hx.

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/content/journal/jgv/10.1099/0022-1317-36-1-199
1977-07-01
2024-04-23
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References

  1. Connor J. D., Sweetman L., Carey S., Stuckey M. A., Buchanan R. A. 1974; Antiviral activity in vitro of adenine arabinoside for vaccinia virus. Antibiotics and Antimicrobial Chemotherapy 6:630–636
    [Google Scholar]
  2. De Garilhe M. P., De Rudder J. 1964; Effét de deux nucleosides de l’arabinoside sur la multiplication des virus de l’herpes et de la vaccine en culture cellulaire. Compte Rendu de l’Academie des Sciences(Paris) 259:2725–2728
    [Google Scholar]
  3. Jones B. R., AL-Hussaini M. 1963; Therapeutic considerations in ocular vaccinia. Transactions of the Opthalmological Society of the United Kingdom 83:613–631
    [Google Scholar]
  4. Jones B. R., Mcgill J. I., Mckinnon J. R., Holt-Wilson A. D., Williams H. P. 1975 In Adenine arabinoside: an Antiviral Agent 1st ed pp 411–416 Edited by Pavan-Langston D., Buchanan R. A., Alford C. A. New York: Raven Press;
    [Google Scholar]
  5. Jones B. R., Patterson A. 1967; Anti-inflammatory drugs and infectious disease: effects of antinflammatory drugs on virus replication in the cornea. Excerpta Medica International Congress series no 163:143–157
    [Google Scholar]
  6. McGill J. I., Coster D. J., Fraunfelder F. T., Holt-Wilson A. D., Williams H. P., Jones B. R. 1975; The use of adenine arabinoside in the management of herpetic keratitis. Transactions of the Ophthalmological Society of the United Kingdom 95:246–249
    [Google Scholar]
  7. Miller F. A., Dixon G. J., Ehrlich J., Sloan B. R. Jun, Mclean I. W. 1968; Antiviral activity of 9-β-D-arabinofuranosyladenine. I. Cell culture studies. Antimicrobial Agents and Chemotherapy 8:136–147
    [Google Scholar]
  8. Pavan-Langston D., Langston R. H. S., Geary P. A. 1974; Prophylaxis and therapy of experimental ocular herpes simplex. Archives of Opthalmology 92:417–421
    [Google Scholar]
  9. Reed L. J., Muench H. 1938; Simple method of estimating 50 percent endpoints. American Journal of Hygiene 27:493–495
    [Google Scholar]
  10. Schabel F. M. Jun 1968; The antiviral activity of 9-β-arabinofuranosyl adenine (ara-A). Chemotherapy 13:321–338
    [Google Scholar]
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