1887

Abstract

SUMMARY

The growth inhibitory effect of human leukocyte and fibroblast interferons was tested . The effect of fibroblast interferon was more pronounced on osteosarcoma cells and the effect of leukocyte interferon was more pronounced on lymphoid cells. This suggests that the capacity of interferon to inhibit cell growth is, in some measure, tissue specific.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-35-3-573
1977-06-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/jgv/35/3/JV0350030573.html?itemId=/content/journal/jgv/10.1099/0022-1317-35-3-573&mimeType=html&fmt=ahah

References

  1. Adams A., Strander H., Cantell K. 1975; Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon. Journal of General Virology 28:207–217
    [Google Scholar]
  2. Cantell K., Hirvonen S., Mogenson K. E., Pyhala L. 1974; Human leukocyte interferon: production purification, stability and animal experiments. In The Production and Use of Interferon for the Treatment and Prevention of Human Virus Infections. In Vitro monograph no 3:35–38
    [Google Scholar]
  3. Edy V. G., Billiau A., De Somer P. 1976; Human fibroblast and leukocyte interferons show different response curves in assay of cell protection. Journal of General Virology 31:251–255
    [Google Scholar]
  4. Fogh J., Trempe G. 1975; New human tumor cell lines. In Human Tumor Cells In vitro chapter 5 pp 115–159 Edited by Fogh J. New York and London: Plenum Press;
    [Google Scholar]
  5. Giovanella B. C., Stehlin I. S., Williams L. J. Jun 1974; Heterotransplantation of human malignant tumours in ‘nude’ thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumor. Journal of the National Cancer Institute 59:921–930
    [Google Scholar]
  6. Gresser L. 1976; Antitumor effects of interferon. In Cancer: A Comprehensive Treatise Edited by Becker F. (in the press.)
    [Google Scholar]
  7. Havell E. A., Vilcek J. 1972; Production of high-titre interferon in cultures of human diploid cells. Antimicrobial Agents and Chemotherapy 2:476–484
    [Google Scholar]
  8. Klein E., Klein G., Nadkarni J. S., Wigzell H., Clifford P. 1967; Surface IgM kappa specificity on a Burkitt lymphoma cell in vitro and in derived culture lines. Cancer Research 28:1300–1310
    [Google Scholar]
  9. Knight E. 1976; Antiviral and cell growth inhibitory activities reside in the same glycoprotein of human fibroblast interferon. Nature, London 262:302–303
    [Google Scholar]
  10. Lockart R. Jun 1973; Criteria for acceptance of a viral inhibitor as interferon and a general description of the biological properties of known interferons. In Interferons and Interferon Inducers pp 11–27 Edited by Finter N. B. Amsterdam, London and New York: North Holland and American Elsevier;
    [Google Scholar]
  11. Stewart W. E., Gresser I., Tovey M. G., Bandu M. T., Le Goff S. 1976; Identification of the cell multiplication inhibitory factors in interferon preparations as interferon. Nature, London 262:300–302
    [Google Scholar]
  12. Strander H., Cantell K. 1966; Production of interferon by human leukocytes in vitro. Annales Medicime Experimentalis et Biologiae Fenniae 44:265–273
    [Google Scholar]
  13. Strander H., Cantell K., Ingimarsson S., Jakobsson P. A., Nilsonne U., Soderberg G. 1976; Interferon treatment of osteogenic sarcoma - a clinical trial. Fogarty Int. Center Proceedings 28 Washington DC: U.S. Government Printing Office; (in the press)
    [Google Scholar]
  14. Strander H., Einhorn S. 1977; Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture. International Journal of Cancer (in the press)
    [Google Scholar]
  15. Strander H., Mogenson K. E., Cantell K. 1975; Production of human lymphoblastoid interferon. Journal of Clinical Microbiology 1:116–117
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-35-3-573
Loading
/content/journal/jgv/10.1099/0022-1317-35-3-573
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error