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Forty-six arboviruses were tested for c.p.e. and/or plaque formation in an amphibian cell line. C.p.e. was observed with a high proportion of the viruses tested. Comparative plaque assay, in the XTC-2 cells at 28 °C and Vero cells at 37 °C, suggests that these systems are comparable in sensitivity and susceptibility to infection. Practical uses of this cell line are discussed.
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