1887

Abstract

SUMMARY

Immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. No antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. A single dose of the same vaccine induced a substantial antibody response and protected normal mice. These data indicate that the antigens in rabies vaccine that induce neutralizing antibody and protect mice are thymus-dependent.

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/content/journal/jgv/10.1099/0022-1317-33-3-535
1976-12-01
2024-04-20
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References

  1. Andersson B., Blomgren H. 1971; Evidence for thymus-independent humoral antibody production in mice against polyvinyl-pyrrolidone and E. coli iipopolysaccharide. Cellular Immunology 3:411–424
    [Google Scholar]
  2. Atanasiu P. 1973; Quantitative assay and potency test of antirabies serum and immunoglobulin. In Laboratory Techniques in Rabies 3rd edn, pp 314–318 Edited by Kaplan M. M., Koprowski H. W.H.O. Monograph series No. 23 Geneva World Health Organization;
    [Google Scholar]
  3. Claman H. N., Mosier D. E. 1972; Cell-cell interactions in antibody production. In Progress in allergy vol 16 pp 40–80 Edited by Kallos P., Waksman B. H., de Week A. Basel: S. Karger;
    [Google Scholar]
  4. Flanagan S. P. 1966; ‘Nude’, a new hairless gene with pleiotropic effects in the mouse. Genetics Research Cambridge 8:295–309
    [Google Scholar]
  5. Gisler R. H., Schumann G., Dukor P. 1974; Functional characteristics of lymphocyte populations from nude mice: requirements for antibody formation in vitro. In Proceedings of the First International Workshop on Nude Mice, Scanticon Aarhus Denmark Oct. 1973, pp 77–87 Edited by Rygaard J., Poulsen C. O. Stuttgart: G. Fisher;
    [Google Scholar]
  6. Kaplan M. M., WiKTOR T. J., Koprowski H. 1975; Pathogenesis of rabies in immunodeficient mice. Journal of Immunology 114:1761–1765
    [Google Scholar]
  7. Katz D. H., Benacerraf B. 1972; The regulatory influences of activated T cells on B cell responses to antigen. In Advances in Immunology vol 15 pp 42–94 Edited by Dixon F. J., Kunkel H. G. New York: Academic Press;
    [Google Scholar]
  8. Koprowski H., Mocarelli P., Wiktor T. J. 1972; Antibody response in vitro to an animal virus: production of rabies virus neutralizing antibodies by mouse cells in culture. Proceedings of the National Academy of Sciences of the United States of America 69:2433–2436
    [Google Scholar]
  9. Pantelouris E. M. 1968; Absence of thymus in a mouse mutant. Nature, London 217:370–371
    [Google Scholar]
  10. Pritchard H., Micklem H. S. 1974; The nude (Nu/Nu) mouse as a model of thymus and T-lymphocyte deficiency. In Proceedings of the First International Workshop on Nude Mice, Scanticon Aarhus Denmark Oct. 1973, pp 127–139 Edited by Rygaard J., Poulsen C. O. Stuttgart: G. Fisher;
    [Google Scholar]
  11. Reed N. D., Manning J. K., Baker P. J., Ulrich J. T. 1974; Analysis of thymus-independent immune responses using nude mice. In Proceedings of the First International Workshop on Nude Mice, Scanticon Aarhus Denmark Oct. 1973, pp 95–103 Edited by Rygaard J., Poulsen C. O. Stuttgart: G. Fisher;
    [Google Scholar]
  12. Taylor R. B., Wortis H. H. 1968; Thymus dependence of antibody response: variation with dose of antigen and class of antibody. Nature, London 220:927–928
    [Google Scholar]
  13. Turner G. S. 1973; Humoral and cellular immune responses of mice to rabies and smallpox vaccines. Nature New Biology 241:90–92
    [Google Scholar]
  14. Turner G. S. 1974; Some observations related to the validity of potency tests for rabies vaccines in Proceedings. International Symposium on Rabies part 11, Lyon 1972, pp 324–331 Symposia series in Immuno-biological Standardization, vol 21 Edited by Regamey, R. H., Hennessen W., Lang R., Perkins F. T., Triau R. Basel: S. Karger;
    [Google Scholar]
  15. Turner G. S., Ballard R. 1976; Interaction of mouse peritoneal macrophages with fixed rabies virus in vivo and in vitro. The Journal of General Virology 30:223–231
    [Google Scholar]
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