An Antigenically Atypical Strain of Variola Virus Free

Abstract

SUMMARY

The Kuwait-5-67 strain of variola virus, although indistinguishable from variola virus in its other properties, behaved atypically in immuno-diffusion tests with antivaccinia serum. The precipitation line pattern produced was similar to that of cowpox virus but lacked one of the main precipitation bands given by all other strains of variola, alastrim and vaccinia viruses tested. Trypsin treatment of cowpox virus preparations revealed the missing precipitation line but did not do so with the Kuwait-5-67 strain. The antivaccinia serum absorbed by Kuwait-5-67 strain lost its ability to interact with this strain, but still gave precipitation lines with variola, vaccinia and cowpox viruses.

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/content/journal/jgv/10.1099/0022-1317-33-3-513
1976-12-01
2024-03-29
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References

  1. Arita I., Shafa E., Kader M. A. 1970; Role of hospital in smallpox outbreak in Kuwait. American Journal of Public Health 60:1960–1966
    [Google Scholar]
  2. Bedson H. S., Dumbell K. R., Thomas W. R. G. 1963; Variola in Tanganyika. Lancet ii:1085–1088
    [Google Scholar]
  3. Chumakov M. P., Rubin S. G., Balayan M. S. 1974; Improvement of the methods for intratypic differentiation of polioviruses. Archiv für die gesamte Virusforschung 46:61–65
    [Google Scholar]
  4. Dumbell K. R., Huq F. 1975; Epidemiological implications of the typing of variola viruses. Transactions of the Royal Society of Tropical Medicine and Hygiene 69:303–306
    [Google Scholar]
  5. Gispen R. 1955; Analysis of pox virus antigen by means of a double diffusion. A method for direct serological differentiation of cowpox. Journal of Immunology 74:134
    [Google Scholar]
  6. Gispen R., Brand-Saathof B. 1974; Three specific antigens produced in vaccinia, variola and monkeypox infections. Journal of Infectious Diseases 139:3, 289–295
    [Google Scholar]
  7. Maltseva N. N., Marennikova S. S. 1976; A method for serological differentiation of close related poxviruses. Acta Virologica (in the press)
    [Google Scholar]
  8. Rondle C. I. M., Dumbell K. R. 1962; Antigens of cowpox virus. Journal of Hygiene 60:41–49
    [Google Scholar]
  9. Sarkar J. K., Mitra A. C. 1966; Severity of smallpox and virulence of causative virus strains. Bulletin of the Calcutta school of Tropical Medicine 14:36–37
    [Google Scholar]
  10. Sarkar J. K., Mitra A. C. 1967; Virulence of variola virus isolated from smallpox cases of varying severity. The Indian Journal of Medical Research 1:13–20
    [Google Scholar]
  11. Sarkar J. K., Mitra A. C. 1968; A search for the causes of severity in smallpox. Journal of the Indian Medical Association 51:272–274
    [Google Scholar]
  12. Shafikova R. A., Marennikova S. S. 1970; Characteristics of properties of variola virus strains isolated from patients with different forms of the disease. Voprosy Virusologyi 6:699–702
    [Google Scholar]
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