1887

Abstract

SUMMARY

Virus-induced RNA synthesis was studied in BHK 21 cells persistently infected with vesicular stomatitis virus (VSV) and rabies virus by labelling RNA synthesized in the presence of actinomycin D. During persistent infection the species of messenger RNA synthesized were similar in size and relative proportions to those seen during acute infection, but there were some minor differences. Full-sized B virion RNA was generally not detected during persistent infection, and new species (probably DI virion RNA) appeared.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-33-2-213
1976-11-01
2021-10-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/33/2/JV0330020213.html?itemId=/content/journal/jgv/10.1099/0022-1317-33-2-213&mimeType=html&fmt=ahah

References

  1. Baltimore D., Huang A. S., Stampfer M. 1970; Ribonucleic acid synthesis of vesicular stomatitis virus. II. An RNA polymerase in the virion. Proceedings of the National Academy of Sciences of the United States of America 66:572–576
    [Google Scholar]
  2. Blatti S. P., Ingles C. J., Lindell T. J., Morris P. W., Weaver R. F., Weinberg F., Rutter W. E. 1970; Structure and regulatory properties of eucaryotic RNA polymerase. Cold Spring Harbor Symposium on Quantitative Biology 35:649
    [Google Scholar]
  3. Bonner W. M., Laskey R. A. 1974; A film detection method for tritium labeled proteins and nucleic acids in polyacrylamide gels. European Journal of Biochemistry 46:83–88
    [Google Scholar]
  4. Chambers V. C. 1957; The prolonged persistence of western equine encephalomyelitis in cultures of strain L cells. Virology 3:62–75
    [Google Scholar]
  5. Crick I., Brown F. 1974; An interfering component of rabies virus which contains RNA. Journal of General Virology 22:147–151
    [Google Scholar]
  6. Doyle M., Holland J. J. 1973; Prophylaxis and immunization in mice by use of virus–free defective T particles to protect against intracerebral infection by vesicular stomatitis virus. Proceedings of the National Academy of Sciences of the United States of America 70:2105–2108
    [Google Scholar]
  7. Emerson S., Wagner R. R. 1972; Dissociation and reconstitution of the transcriptase and template activities of vesicular stomatitis B and T virions. Journal of Virology 10:297–309
    [Google Scholar]
  8. Ginsberg H. S. 1958; The significance of the viral carrier state in tissue culture systems. Progress in Medical Virology 1:36–58
    [Google Scholar]
  9. Grubmann N. J., Moyer S. A., Banerjee A. K., Ehrenfeld E. 1975; Subcellular localization of vesicular stomatitis virus messenger RNAs. Biochemical and Biophysical Research Communication 62:531–538
    [Google Scholar]
  10. Henle W. 1963; Interference and interferon in persistent viral infections of cell cultures. Journal of Immunology 91:145–150
    [Google Scholar]
  11. Holland J. J., Villarreal L. P. 1974; Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase. Proceedings of the National Academy of Sciences of the United States of America 71:2956–2960
    [Google Scholar]
  12. Holland J. J., Villarreal L. P. 1975; Purification of defective interfering T particles of vesicular stomatitis and rabies virus generated in vivo in brains of newborn mice. Virology 67:438–449
    [Google Scholar]
  13. Holland J. J., Villarreal L. P., Welsh R. M., Oldstone M. B. A., Kohne D., Lazzarini R., Scolnick E. 1976; Long-term persistent vesicular stomatitis virus and rabies virus infection of cells in vitro. Journal of General Virology 33:193–211
    [Google Scholar]
  14. Holland I. J., Villarreal L. P., Breindl M. 1976; Factors involved in the generation and replication of rhabdovirus defective T particles. Journal of Virology 17:805–815
    [Google Scholar]
  15. Huang A. S. 1973; Defective interfering viruses. Annual Review of Microbiology 27:101–117
    [Google Scholar]
  16. Huang A. S., Baltimore D. 1970; Ribonucleic acid synthesis of vesicular stomatitis virus. IV. Transcription by standard virus in the presence of defective interfering particles. Journal of Virology 9:909–916
    [Google Scholar]
  17. Huang A. S., Manders E. K. 1972; Ribonucleic acid synthesis of vesicular stomatitis virus. IV. Transcription by standard virus in the presence of defective interfering particles. Journal of Virology 9:909–916
    [Google Scholar]
  18. Hummeler K., Koprowski H., Wiktor T. J. 1967; Structure and development of rabies virus in tissue culture. Journal of Virology 1:152–170
    [Google Scholar]
  19. Kawai A., Matsumoto S., Tanabe K. 1975; Characterization of rabies viruses recovered from persistently infected BHK cells. Virology 67:520–533
    [Google Scholar]
  20. Knipe D., Rose J. K., Lodish H. F. 1975; Translation of individual species of vesicular stomatitis viral mRNA. Journal of Virology 15:1004–1011
    [Google Scholar]
  21. Koprowski H. 1974; Rabies and parainfluenza viruses. In Mechanisms of Virus Disease, ICN–UCLA Symposia on Molecular and Cellular Biology pp 169–186 Edited by Robinson W. S., Fox C. F. Menlo Park, California: W. A. Benjamin, Inc;
    [Google Scholar]
  22. Laskey R. A., Mills A. D. 1975; Quantitative film detection of 3H and 14C in polyacrylamide gels in fluorography. European Journal of Biochemistry 56:335
    [Google Scholar]
  23. Matsumoto S. 1963; Electron microscope studies of rabies virus in mouse brain. Journal of Cell Biology 19:565–576
    [Google Scholar]
  24. Mudd J. A., Summers D. F. 1970; Protein synthesis in vesicular stomatitis virus–infected HeLa cells. Virology 42:328–340
    [Google Scholar]
  25. Palma E. L., Huang A. S. 1974; Cyclic production of vesicular stomatitis virus caused by defective interfering particles. Journal of Infectious Disease 129:402–410
    [Google Scholar]
  26. Perrault I., Holland J. J. 1972a; Variability of vesicular stomatitis virus autointerference with different host cells and virus serotypes. Virology 50:148–170
    [Google Scholar]
  27. Perrault J., Holland J. J. 1972b; Absence of transcriptase activity on transcription–inhibiting ability in defective interfering particles of vesicular stomatitis virus. Virology 50:159–170
    [Google Scholar]
  28. Pringle C. R. 1970; Genetic characteristics of conditional lethal mutants of vesicular stomatitis virus induced by 5–fluorouracil, azacytidine and ethyl methane sulfonate. Journal of Virology 5:559–567
    [Google Scholar]
  29. Reichmann M. E., Villarreal L. P., Kohne D., Lesnaw J., Holland J. J. 1974; RNA polymerase activity and poly (A) synthesizing activity in defective T particles of vesicular stomatitis vius. Virology 58:240–249
    [Google Scholar]
  30. Rose J. K., Knipe D. 1975; Nucleotide sequence complexities, molecular weights and poly (A) content of the vesicular stomatitis virus mRNA species. Journal of Virology 15:994–1003
    [Google Scholar]
  31. Roy P., Bishop D. H. L. 1972; The genome homology of vesicular stomatitis virus and defective T particles and evidence for sequential transcription of the virion RNA. Journal of Virology 9:946–955
    [Google Scholar]
  32. Sokol F., Clark H. F. 1973; Phosphoproteins, structural components of rhabdoviruses. Virology 52:246–263
    [Google Scholar]
  33. Sokol F., Kuwert E., Wikton T. J., Hummeler K., Koprowski H. 1968; Purification of rabies virus grown in tissue culture. Journal of Virology 2:836–849
    [Google Scholar]
  34. Villarreal L. P., Holland J. J. 1974; Transcribing complexes in cells infected by vesicular stomatitis virus and rabies virus. Journal of Virology 14:441–450
    [Google Scholar]
  35. Villarreal L. P., Breindl M., Holland J. J. 1976; Determination of molar ratios of vesicular stomatitis virus induced RNA species in BHK 21 cells. Biochemistry 15:1663–1667
    [Google Scholar]
  36. Walker D. L. 1964; The viral carrier state in animal cell cultures. Progress in Medical Virology 6:111–148
    [Google Scholar]
  37. Wilcox W. C. 1959; II. The role of autointerference in the production of cell populations resistant to cytotoxic effects of Newcastle disease virus. Virology 9:45–55
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-33-2-213
Loading
/content/journal/jgv/10.1099/0022-1317-33-2-213
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error