1887

Abstract

SUMMARY

The neuraminidase inhibitor 2-deoxy-2,3-dehydro--trifluoroacetylneuraminic acid (FANA) inhibits the multicycle replication of influenza viruses in tissue culture. Influenza virus grown in the presence of FANA contains neuraminic acid on its envelope which then serves as receptor for other virus particles causing extensive aggregation. Thus, FANA inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid from the virus envelope.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-33-1-159
1976-10-01
2024-12-08
Loading full text...

Full text loading...

/deliver/fulltext/jgv/33/1/JV0330010159.html?itemId=/content/journal/jgv/10.1099/0022-1317-33-1-159&mimeType=html&fmt=ahah

References

  1. Hirst G. K., Pons M. W. 1973; Mechanism of influenza recombination. II. Virus aggregation and its effect on plaque formation by so called noninfective virus. Virology 56:620–632
    [Google Scholar]
  2. Kilbourne E. D., Palese P., Schulman J. L. 1974; Inhibition of viral neuraminidase as a new approach to the prevention of influenza. Perspectives in Virology IX:99–113
    [Google Scholar]
  3. Klenk H. D., Choppin P. W. 1970; Glycosphingolipids of plasma membranes of cultured cells and an enveloped virus (SV5) grown in these cells. Proceedings of the National Academy of Sciences of the United States of America 66:57–64
    [Google Scholar]
  4. Klenk H. D., Compans R. W., Choppin P. 1970; An electron microscopic study of the presence or absence of neuraminic acid in enveloped viruses. Virology 42:1158–1162
    [Google Scholar]
  5. Meindl P., Tuppy H. 1973; 2-Deoxy-2, 3-dehydrosialic acid. III. Synthesis and properties of 2-deoxy-2, 3-dehydro-neuraminic acid and of new V-acyl derivatives. Monatshefte fiir Chemie 104:402–412
    [Google Scholar]
  6. Meindl P., Bodo G., Palese P., Schulman J. L., Tuppy H. 1974; Inhibition of neuraminidase activity by derivatives of 2-deoxy-2, 3-dehydro-V-acety)neuraminic acid. Virology 58:457–463
    [Google Scholar]
  7. Palese P., Schulman J. L., Bodo G., Meindl P. 1974a; Inhibition of influenza and parainfluenza virus replication in tissue culture by 2-deoxy-2, 3-dehydro-A-trifluoroacteylneuraminic acid (FANA). Virology 59:490–498
    [Google Scholar]
  8. Palese P., Tobita K., Ueda M., Compans R. W. 1974b; Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virology 61:397–410
    [Google Scholar]
  9. Schulman J. L., Palese P. 1975; Susceptibility of different strains of influenza A virus to the inhibitory effects of 2-deoxy-2, 3-dehydro-/V-trifluoro-acetylneuraminic acid (FANA). Virology 63:98–104
    [Google Scholar]
  10. Schulze I. T. 1975; Effects of sialylation on the biological activities of the influenza virion. In Negative Strand viruses pp 161–175 Edited by Barry R. D., Mahy B. W. J. New York: Academic Press;
    [Google Scholar]
  11. Sugiura A., Tobita K., Kilbourne E. D. 1972; Isolation and preliminary characterization of temperature sensitive mutants of influenza virus. Journal of Virology 10:639–647
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-33-1-159
Loading
/content/journal/jgv/10.1099/0022-1317-33-1-159
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error