1887

Abstract

SUMMARY

The present study was undertaken to investigate the mechanism of interferon production by mouse spleen cells co-cultivated with BHK-HVJ cells, i.e. baby hamster kidney cells persistently infected with the HVJ (or Sendai) strain of parainfluenza 1 virus. Cytochalasin B appears to inhibit an early stage in the process and colchicine a relatively late stage. It is suggested that microfilaments and microtubules may play an important role at an initial stage of interferon production in this system.

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/content/journal/jgv/10.1099/0022-1317-33-1-1
1976-10-01
2024-04-18
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References

  1. Borisy G. G., Taylor E. W. 1967; The mechanism of action of colchicine. Journal of Cell Biology 34:525–533
    [Google Scholar]
  2. Henney C. S., Bubbers J. E. 1973; Antigen-T lymphocyte interactions: Inhibition by cytochalasin B. Journal of Immunology 111:85–90
    [Google Scholar]
  3. Ito Y., Kimura Y., Nagata I., Kunii A. 1974; Production of interferon like substance by mouse spleen cells through contact with BHK cells persistently infected with HVJ. Virology 60:73–84
    [Google Scholar]
  4. Nagata I., Kimura Y., Ito Y., Tanaka T. 1972; Temperature-sensitive phenomenon of viral maturation observed in BHK cells persistently infected with HVJ. Virology 49:453–461
    [Google Scholar]
  5. Wessells N. K., Spooner B. S., Ash J. F., Bradley M. O., Luduena M. A., Taylor E. L., Wrenn J. T., Yamada K. M. 1971; Microfilaments in cellular and developmental processes. Science, New York 171:I35–143
    [Google Scholar]
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